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Application Overview
Advances in µ - XRF
The macroscopic properties of technical materials are often determined by their elemental composition. Because most technical materials are inhomogeneous analytical methods are required that allow elemental analysis of these inhomogeneities - not only as a point by point measurement but also as a complete 2D-distribution. Micro X-ray fluorescence (µ XRF) has recently been established for this purpose. more
Pushing the Boundaries of Fluorescence Imaging
Olympus has recently launched a range of versatile fluorescence research microscope systems. The xcellence line covers advanced live cell techniques, including real-time, high-speed imaging, TIRFM & HILO (cell^tirf), and photo control such as FRAP, FLIP & photo activation (cell^frap). With a series of new features, this portfolio enables users to continue advancing their microscopy research. more
Storming the Barriers of Light
Live cell imaging is one of the most rapidly evolving areas of life science research. The more researchers see, the more they want to see and this is driving innovation in imaging technologies to see deeper, clearer and faster. While light is the fundamental enabling factor in optical microscopy, light can also create significant barriers when trying to image biological samples. Visible light, for example, cannot pass easily through living tissue and is scattered, preventing it from reaching areas of interest in thicker specimens. more
Fluorescence Microscope for High Sensitivity
For the three „global killer diseases", HIV/ AIDS, TB and Malaria, fast and reliable diagnosis is crucial for modern laboratory practices. In resource-limited settings, for example, TB is diagnosed by using sputum smears with microscopy for which fluorescence based microscopic techniques have shown to be much more sensitive than transmitted light microscopy, where M. tuberculosis bacilli in a significant number of cases are not seen. more
Correlative Microscopy for Material Analysis
Austempered Ductile Iron (ADI) excels through strength, wear resistance and toughness - characteristics that make ADI the material of choice for use in combustion engines and gear box components. This means that safety aspects are also involved in addition to purely functional aspects. For this reason, changes in the ADI production process need to be monitored with respect to the material´s characteristics and must be optimized systematically. For the micro- and nanoscopic analysis of the structure and precipitations, scientists typically use both light and electron microscopes. more
TIRF
Changes in the intracellular Ca2+ concentration ([Ca2+]i) accompany many diverse biological phenomena from neuronal excitability and muscle contraction to activation of transcription and cell death. more
Surface Plasmon Enhanced TIRF Imaging
Total Internal Reflection Fluorescence Microscopy (TIRFM) is a powerful technique for imaging dynamic membrane events in living cells. However the information gained from TIRFM may be limited by the intensity of the florescence signal and by background noise emanating from the inner part of the cell. Here we describe how Surface Plasmon Mediated Fluorescence Microscopy (SPMFM) can enhance TIRFM by increasing the fluorescence signal 5-6 fold and by reducing background noise dramatically. more
Analytical Power for the Sub-Nanometer World
In recent years there has been an ongoing trend to design specialized scanning electron microscopes, dedicated to specific applications. As a result two different system configurations in the SEM market have emerged: One configuration is dedicated to deliver high resolution imaging. The other configuration is dedicated to optimized analytical performance. However, these two diverging development lines force users to decide whether they will limit their research to high resolution imaging or optimized analytical investigations. more
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