May. 16, 2013
Applications

Improving Drug Delivery with Macrophage Targeting

  • Fig.1: Targeted drug delivery using a stealth liposome approach. Liposomes (green) are directed toward the CD163 M2 macrophage marker (magenta); with nuclei stained with Hoechst 33342. Captured using the Olympus FluoView FV10i fully automated confocal laser scanning fluorescence microscope system.Fig.1: Targeted drug delivery using a stealth liposome approach. Liposomes (green) are directed toward the CD163 M2 macrophage marker (magenta); with nuclei stained with Hoechst 33342. Captured using the Olympus FluoView FV10i fully automated confocal laser scanning fluorescence microscope system.

Confocal laser scanning microscopy (CLSM) is a powerful tool, advancing research across a variety of disciplines. With the many challenges faced by the pharmaceutical industry, ensuring a drug reaches its target site is a key priority. This article describes how CLSM is central to the development of a novel drug delivery system, where the authors have created an advanced stealth liposome approach. These liposomes are precisely tracked using the fully automated Olympus FluoView FV10i, to study the selective targeting of macrophages, which play a vital role in a range of conditions including cancer. Read more to discover how CLSM is pushing the boundaries of biomedical research...

Contacts
Anders Etzerodt
Department of Biomedicine, Aarhus University, The Netherlands

Ralf Schäfer (corresponding author via email request button)
Olympus Europa Holding GMBH
Hamburg, Germany

 

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