Nov. 12, 2013
Applications

Super-Resolution Microscopy

Exploring the Third Dimension

  • Super-Resolution was initially restricted to definition-enhancement in lateral direction. The picture was acquired using the latest development in STED super-resolution. It shows a comparison of confocal versus 3D STED sections that prove super-resolution both horizontally and vertically. The Leica TC SP8 STED 3X offers a technology that allows data acquisition at any position in the sample at isotropic super-resolution.Super-Resolution was initially restricted to definition-enhancement in lateral direction. The picture was acquired using the latest development in STED super-resolution. It shows a comparison of confocal versus 3D STED sections that prove super-resolution both horizontally and vertically. The Leica TC SP8 STED 3X offers a technology that allows data acquisition at any position in the sample at isotropic super-resolution.

Visual perception is often regarded as the most impressive of our senses. And many attempts have been made to preserve optical impressions - or enhance them to augment the fun. Optical imaging devices have one annoying disadvantage, though: the range of sharp imaging is limited. This limited range is called "depth of field". Although our eyes feature the same limitation, our brain has clever means to filter only the sharp parts of the whole image into our consciousness. We realize that fraud at the latest when we look at a photograph and wonder why there are unsharp regions.

Author
Dr. Rolf T. Borlinghaus
Senior Scientist
Leica Microsystems CMS GmbH
Mannheim, Germany

Contact

Leica Microsystems GmbH
Am Friedensplatz 3
68165 Mannheim
Germany
Phone: +49 621 7028 2801
Telefax: +49 621 7028 8011

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