Leica EM Cryo CLEM - Correlating Samples in their Native State

One System to Serve Your Workflow Needs in CLEM

  • Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.
  • Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.
  •  Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.
  •  Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.
  •  Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.
  •  Leica EM Cryo CLEM – One System to Serve Your Workflow needs in Correlative Light and Electron Microscopy.

The innovative Leica EM Cryo CLEM set for widefield light microscopy with the Leica DM6 FS represents the state-of-the art solution for analysis of cryo samples in the cryo light and electron microscope. It allows rapid screening of large areas under the fluorescence light microscope and fast determination of regions of interest which can then be quickly recognized in the electron microscope. This can reduce up to 50% of the user interaction on the cryo electron microscope and helps users save time.  In addition, the image data from both sources can be combined, resulting in a deeper understanding of the analyzed sample.

The Leica EM Cryo CLEM system consists of a fluorescence light microscope with cryo stage, cryo objective, and a cyro transfer shuttle. This keeps cryo-fixed samples under cyro conditions during imaging in the fluorescence light microscope and during transfer to the EM.

Find What You Are Looking for
Leica Microsystems developed the world's first commercially available cryo CLEM objective - Leica HCX PL APO 50x / 0,90 / WD 0,28 mm - to localize fluorescence labeled target structures.
Its low working distance of 0.28 mm ensures high resolution cryo imaging.

Time Saving
Reduce up to 50% of the user interaction on the cryo EM due to well preserved sample quality and accurately located target structures.

Ease of Use
Sensor-controlled stage temperature function.
Ease of use with the intuitive sample transfer and loading system.

Cost Savings
Significantly reduced cryo EM user operation costs due to reduced target structure search time.

Detailed information on Leica EM ICE you may find here
If you require more information, please contact us via Email here

 

Contact

Leica Microsystems GmbH
Ernst-Leitz-Str. 17-37
D-35578 Wetzlar
Germany
Phone: +49 6441 29 4000
Telefax: +49 6441 29 4155

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