Sample Preparation for SEM, TEM and AFM

Agar Scientific Announces the Availability of SMART Grids from Dune Sciences

Schematic to illustrate functionality of a Dune BioGrid capturing specific viruses more

Agar Scientific announce their appointment by Dune Sciences for the supply of SMART Grids to simplify nano- and bioanalysis sample preparation. Applying surface chemistry, SMART Grids characterization substrates capture both biological and nanomaterials through attraction or self-assembly enabling opportunities for integrative analysis and processing. SMART Grids are tools for enhanced analytical characterization and the development of new nanoscale materials.

For the first time, this cross-disciplinary tool integrates the combined capabilities of electron microscopy and surface science with electronic and optical interrogation in a single sample to provide comprehensive understanding of structural, chemical and functional characteristics at the nanoscale.

SMART Grids are now available with either SiO₂ or 5nm Si₃N₄ membranes for reproducible and accurate imaging and metrology. These ultrathin membranes are electron transparent and can be hydrophilic, hydrophobic or charged to provide application-specific substrates.

Three different types are available:

• TEM grids can serve as an active component of research through manipulation of surface-driven interactions and by enabling multi-technique analysis on the same sample.


• NanoGrids are available with a range of active surfaces to enable uniform dispersion and accurate characterization of many different types of materials by liquid or vapour phase deposition. NanoPlus Grids are hydrophilic and have membrane windows with positive surface charge. Particles with negative partial surface charge "stick" to the grid surface through electrostatic interaction by simply immersing in a drop of solution and then rinsing.


• BioGrids are functionalized SMART Grids that simplify and standardize sample preparation for biological electron microscopy and cryoEM. The surface provide affinity for proteins, viruses, or other biomolecules through both non-specific bonding and analyte-specific bonding.

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Keywords: AFM Agar Scientific Bioanalysis Dune Sciences Electron Microscopy nanoanalysis Sample Preparation SEM SMART Grid TEM

Agar Scientific Ltd.
Unit 7, M11 Business 0
Stansted, Essex CM24 8GF
UK

Tel: 44 1279 813 519
Fax: 44 1279 815106
Web: http://www.agarscientific.com

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