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Speeding up Brain Mapping and 3-D Reconstruction
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Electron microscopy and analysis instruments from Carl Zeiss are redefining the science of brain mapping and 3-D reconstruction. Wide-field, high resolution imaging, huge data storage and manipulation capabilities plus highly automated sample preparation techniques are yielding research results 100-times, or more, faster than ever before. As a result, a number of high-ranking research institutes are adopting these remarkable instruments, and are producing phenomenal breakthroughs in understanding the human brain.
For example, a University of Texas lab specializes in three-dimensional reconstruction by stacking images from serial 45nm-thick sections. According to John Mendenhall, a microscopist at the Center for Learning and Memory, their approach to accelerating the analysis is to "map the largest single field of view at minimum resolution, 2-3 nm pixels at the specimen level, needed for benchmarking ultrastructural features. With enough sections, sufficient resolution and the large field-of-view, we can approach neural circuit-scale volumes that include essential sub-cellular and connectivity detail."
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Keywords: Brain Mapping Carl Zeiss Electron analysis Electron Microscopy NTS
Carl Zeiss Microscopy - Nano Technology Systems
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Tel: +49 7364 20 22 94
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Web: http://www.zeiss.com/microscopy
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