Imaging & Microscopy en Live-Cell Microscopy: Individual Receptors Caught at Work Using a revolutionary live-cell microscopy technique, an international team of scientist has observed for the first time individual receptors for hormones and widely used drugs at work in intact cells. Fri, 20 Oct 2017 05:45:00 +0000 The Ergonomic Choice for Clinical and Life Science Microscopy The Olympus BX53 microscope is designed with ergonomics in mind, enhancing comfort during long periods of use. Its ergonomic headpiece enables users to adjust the inclination angle, extend the tube and adjust its height, improving productivity through comfortable working. Thu, 19 Oct 2017 04:41:00 +0000 Imaging Rotational Motions in Live Cells Dr. Ning Fang of the Chemistry Department at Georgia State University has developed a new optical imaging technique, Single Particle Orientation and Rotational Tracking (SPORT), to image rotational motions in live cells and ultimately target cancer cells. Fang’s invention is a differential interference contrast (DIC) microscopy-based imaging tool, which tracks plasmonic nanoparticles of various shapes and sizes. The SPORT is a modified commercial microscope with five-dimensional single- particle tracking capabilities. Wed, 18 Oct 2017 05:57:00 +0000 Zeiss Expands Laboratory-based X-ray Microscopy Solution in Partnership with Xnovo Carl Zeiss Microscopy today announced an exclusive strategic partnership agreement with Xnovo Technology expand the laboratory-based diffraction contrast tomography technique, commercialized as LabDCT, on ZEISS Xradia 520 Versa. Tue, 17 Oct 2017 12:05:00 +0000 PicoQuant has Released the New Software for the Analysis of Quantum Correlations PicoQuant has released the QuCoa software package, an integrated solution for data acquisition and analysis using the unique T2 time-tagging mode of PicoQuant's TCSPC electronics. Mon, 16 Oct 2017 11:04:00 +0000 Hübner Photonics Cements Distribution Network Hübner Photonics, a division of the Hübner Group, announced an expansion of their sales channels around the world. Recently appointing Lahat Technologies in Israel, Laser Lines in UK, DynaSense Photonics in China and Optoprim in France, Hübner Photonics’ goal is to align their distribution network with that of their laser technology company, Cobolt. Wed, 11 Oct 2017 13:46:00 +0000 Olympus`DP74 Camera: Your Image Matters Olympus’ 20.7 megapixel DP74 camera provides true-to-life images across many different applications, with color and fluorescent samples alike. With intelligent features for the first time available in a camera it brings quality and speed to any microscope where it is connected to. Click to watch the video now! Tue, 10 Oct 2017 06:02:00 +0000 Nanoscopy On-a-Chip The German Physicist Ernst Abbe has discovered the fundamental diffraction limit of optical resolution in 1873. Even being depicted on his grave, this relation was carved in stone for about 100 years until scientists started to reveal how to trick physics and build microscopes that enable much better resolutions than fixed by Abbe‘s famous formula. The importance of these developments is underlined by 2014‘s Nobel Prize in Chemistry being awarded to Eric Betzig, William E. Moener, and Stefan W. Hell. Sat, 07 Oct 2017 06:22:00 +0000 Atomic Force Microscopy: Breaking the Time Barrier Oak Ridge National Laboratory scientists have developed a technique for making ultrafast measurements using atomic force microscopy, which previously could only investigate slow or static material structures and functions. Fri, 06 Oct 2017 04:51:00 +0000 Nobel Prize in Chemistry 2017 for Cryo-Electron Microscopy Jacques Dubochet, University of Lausanne, Switzerland, Joachim Frank, Columbia University, New York, USA and Richard Henderson, MRC Laboratory of Molecular Biology, Cambridge, UK received the Nobel Prize 2017 in Chemistry for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution. Wed, 04 Oct 2017 10:53:00 +0000 Full Spectral Freedom for Multicolor, Deep In Vivo Imaging: SP8 DIVE Deep In Vivo Explorer First Spectrally Tunable Solution for Multicolor, Multiphoton Imaging The new SP8 DIVE Deep In Vivo Explorer is the first fully tunable spectral multiphoton microscope for deep in vivo imaging. The system adapts to every existing and new transgenic marker with only a few mouse clicks. The integrated 4Tune, a unique spectral non-descanned detection unit, replaces conventional, fixed emission filters and provides unlimited flexibility for multicolor deep in vivo imaging. Wed, 04 Oct 2017 09:17:00 +0000 Open-Source Microscope: Tracking Live Brain Activity with the New NeuBtracker Microscope A team of scientists from the Helmholtz Zentrum München and the Technical University of Munich (TUM) has successfully developed a new type of microscope. The so-called NeuBtracker is an open source microscope that allows to observe neuronal activities of zebrafish without perturbing their behavior. Wed, 04 Oct 2017 07:36:00 +0000 Faster Imaging at the Nano Level Tufts researchers have discovered a new, faster way to image materials at the nano level, an advance that could speed the detection of cancer and assist in the development of new high-tech materials. The new method was discovered by Igor Sokolov, a professor of mechanical engineering, and Maxim Dokukin, a postdoctoral scholar in Sokolov’s lab. Thu, 28 Sep 2017 05:43:00 +0000 Art in Focus of Synchrotron Microscopes The X-ray and infrared microscopes at ID21 beamline, European Synchrotron Radiation Facility, are regularly used to get insight into artistic materials via elemental, chemical and phase 2D maps acquired on micrometric fragments. The compounds constituting the artistic matter (original ingredients, degradation products, conservation treatments, pollutants…) can be identified and localized at the micron scale. Information can thus be obtained about manufacturing recipes and degradation mechanisms. Introduction Thu, 21 Sep 2017 12:23:00 +0000 Read & Win: Infrared and Raman Spectroscopic Imaging Infrared and Raman Spectroscopic Imaging is a powerful and widely used tool.  Many developments have taken place with the method in the last decades due to many advances in instrumentation and software. This reference book, in its second edition, reflects these developments in this exciting area of research. New methods like the combination of IR imaging with AFM has enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers, thus launching a multiplicity of new applications in material science. Thu, 21 Sep 2017 12:13:00 +0000 True Color Rendering in Microscopy LED illumination is fast becoming a bright, reliable and energy-efficient alternative to halogen illumination in microscopy. However, there are concerns over the ability of LEDs to render the actual colors of a stained specimen. A dedicated design of the LED light source can closely mimic halogen illumination and have a positive impact on the ability to distinguish colors in a specimen. This means that durability and energy-efficiency can go hand-in-hand with confidence in colors and confidence in diagnoses. Thu, 21 Sep 2017 10:59:00 +0000 Multiphoton Microscopy The colorful picture shows colon tumor cells, fluorescently labeled and lineage traced from a multicolor tracer. The gray color codes for the second harmonic generation (SHG) signal from Collagen 1. Lineage traced tumor cells are shown in magenta, blue, green, yellow, and red. All channels were recorded with two-photon excitation, using the SP8 DIVE by Leica Microsystems. Sample and image were kindly provided by J. van Rheenen, H. Snippert, Utrecht (the Nederlands,) and I. Steinmetz, Leica Microsystems Mannheim. Thu, 21 Sep 2017 10:41:00 +0000 Ultrafast Microscopic Movie Revealing Complete Structural Dynamics Femtosecond (fs) laser-material interactions have been extensively studied in the past. However, there still lacks a clear understanding for even the simplest morphological responses; a direct visualization of the complete ultrafast structural dynamics has never been realized. Interestingly, fs laser-induced morphological changes often drastically alter a material’s physical properties. Thu, 21 Sep 2017 08:12:00 +0000 New Microscope Technology Gives a Detailed Look at Structure and Composition of Materials At their core, electron microscopes work a lot like a movie projectors. A high-powered beam passes through a material and it projects something — usually something we really want to see — onto a screen on the other side. With most electron microscopes, however, capturing data is like trying to project a movie onto a dirty screen that is too small to see the whole projection. But a new camera technology, tested by researchers at Drexel University, is enabling the microscopes to present a clearer, more complete and detailed look at their featured presentation. Thu, 21 Sep 2017 08:09:00 +0000 Molecular Mapping Beyond the Diffraction Limit Non-destructive and label-free molecular mapping at the nanoscale under ambient conditions challenges the limits of most analytical techniques. Tip-Enhanced Optical Spectroscopy (TEOS) is one of the very few techniques capable of achieving this. In this article, we discuss the principles of TEOS, its application to nanoscale chemical charaterisation in different areas and how it can be combined with other methods to provide multi-parameter imaging at the nanoscale. Thu, 21 Sep 2017 07:27:00 +0000 Uncovering the Potential of Graphene Oxide Membranes Graphene oxide (GO) is a two-dimensional nanomaterial composed of a graphene monolayer highly functionalized with oxygen-containing chemical groups. Recently, GO nanostructures have attracted great interest due to their exceptional physicochemical properties for many applications. Crucially, GO sheets can be converted into a graphene-like material, named reduced graphene oxide (rGO), by relatively easy, scalable and cost-effective synthesis methods. GO has therefore arisen as a key element in obtaining graphene-like materials at an industrial scale. Wed, 20 Sep 2017 13:30:00 +0000 Lensless Imaging: Fluorescence Microscopy on a Chip Fluorescence microscopy gives researchers incredible power to illuminate the tiniest structures and capture the real-time activities of live cells by tagging biological molecules with a veritable rainbow of fluorescent dyes. This power comes at a cost: The technology can be expensive and time-consuming and, so far, has resisted attempts at automation. Wed, 20 Sep 2017 10:07:00 +0000 Friction Layer of Automotive Brake Pads Wear of friction materials symbolizes a challenge since several chemical compounds are being released. There is still a lack of information about chemical composition of friction layer and the wear debris. It is necessary to develop analytical methods, which make it possible to correlate microstructure and chemistry of the friction layer. SEM, EDS with Raman microspectroscopy were introduced as a possible combination of analytical techniques. Wed, 20 Sep 2017 08:55:00 +0000 Deceptively Simple SCAPE 4D Microscope brings Major Innovation to Live Cell and Whole Animal Imaging Advances in confocal, two-photon and light-sheet microscopy have rapidly advanced the understanding of cellular and subcellular structures and processes. Live cell and whole animal imaging could be on the verge of even more breakthroughs following the publication in Nature Photonics of work by a team of Columbia University scientists using the fast and ultra-sensitive Andor Zyla sCMOS camera. Mon, 18 Sep 2017 10:58:00 +0000 New Technologies for 3D Surface Metrology Sensofar Metrology has developed new innovative software features for their 3-in-1 S-line 3D surface metrology systems. Two new measurement technologies – Confocal Fusion and Continuous Confocal - represent significant new developments in 3D surface metrology, and underline Sensofar’s technological lead in this field. Mon, 18 Sep 2017 05:51:00 +0000