Imaging & Microscopy en Cryo-EM: How Bacteria Turbocharged their Motors Using detailed 3D images, researchers have shown how bacteria have evolved molecular motors of different powers to optimise their swimming. The discovery, by a team from Imperial College London, provides insights into evolution at the molecular scale. Fri, 12 Jan 2018 17:08:00 +0000 MicroED: Determining the Structure of Proteins with Atomic Precision Biochemistry and structural biology are surprisingly — at least to the uninitiated — visual fields. This is especially true in the study of proteins. Scientists like to see the structure of proteins within cells to help them truly understand how they work, how they don’t work or how they can be modified to work as they should. That is, how they can be targeted with drugs to cure disease. Mon, 08 Jan 2018 14:59:00 +0000 Trends in Microscopy: Bridging the Worlds The conference Trends in Microscopy 2018: Bridging the Worlds (TIM2018) will take place on 12-15 March 2018 in Düsseldorf and is co-organized by German BioImaging-Society for Microscopy and Image Analysis (GerBI-GMB), University of Konstanz, and the local organizers Dr. Stefanie Weidtkamp-Peters (Heinrich Heine University Düsseldorf) and Dr. Astrid Schauss (University of Cologne). Thu, 04 Jan 2018 05:03:00 +0000 Single Metalens Focuses all Colors of the Rainbow in One Point Metalenses — flat surfaces that use nanostructures to focus light — promise to revolutionize optics by replacing the bulky, curved lenses currently used in optical devices with a simple, flat surface.  But, these metalenses have remained limited in the spectrum of light they can focus well. Now a team of researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has developed the first single lens that can focus the entire visible spectrum of light — including white light — in the same spot and in high resolution. Wed, 03 Jan 2018 13:22:00 +0000 The Imaris Version 9.1: A Revolution in the Visualization of Complex Microscopy Datasets Bitplane, an Oxford Instruments Company and leader in 3D/4D microscopy image visualisation and analysis has today launched Imaris version 9.1 along with  the newest member of the Imaris family, Imaris Stitcher. Many experiments require viewing an entire organism, organ, or tissue while also resolving features at the subcellular level. This problem can be solved in one of two ways: Thu, 28 Dec 2017 17:06:00 +0000 WITec Suite Five Software Now Features Active Focus Stabilization WITec, industry-leading manufacturer of Raman imaging and correlative microscopy systems, has started shipping its Suite Five data acquisition, evaluation and processing software with the new ability to compensate for thermal and mechanical variations during long-term measurements. Fri, 22 Dec 2017 10:26:00 +0000 Pico Quant´s FluoTime 300 Spectrometer PicoQuants FluoTime 300 fluorescence lifetime spectrometer is now available with double monochromators in excitation and emission. Due to the very high stray light rejection of these monochromators, the signal to noise ratio of the spectrometer is increased to more than 29.000:1 (RMS) using the standard water Raman test. Thu, 21 Dec 2017 12:32:00 +0000 ESO and Toptica Sign Contract for ELT Laser Sources Toptica signed an updated contract with the European Southern Observatory (ESO) for the production of four more lasers to be used in the adaptive optics system of the Extremely Large Telescope (ELT). Tue, 19 Dec 2017 15:40:00 +0000 Zeiss Acquires Majority Stake in Italian X-Ray Provider Bosello High Technology Zeiss (Germany) and Bosello High Technology (Italy) have announced that the Zeiss Group will acquire a majority stake in the provider of industrial X-ray solutions. Tue, 19 Dec 2017 15:18:00 +0000 Super-Resolution Microscopy: Adapting DNA-PAINT Technology to Confocal Microscopes Cell biologists traditionally use fluorescent dyes to label and visualize cells and the molecules within them under a microscope. With different super-resolution microscopy methods, they can even light up single molecules and see their complex interactions with one another. However, the microscopy hardware required to do this is highly specialized, expensive, and requires operators to have unique skills; hence, such microscopes are relatively rare in laboratories around the world. Fri, 15 Dec 2017 10:46:00 +0000 Live-Cell Computer Tomography: New Imaging Technology for Advance Disease Diagnostics Medical imaging technology like MRIs and CT scans have revolutionized the way patients are diagnosed with injuries and disease by enabling doctors to non-invasively look beneath the patient’s skin. Now, similar imaging advances may soon propel discoveries for the biomedical research community with a new technology ---called live-cell, CT (or LCCT) --- that was recently developed by a team of ASU inventors to enable biologists to explore the inside of living, single cells. Thu, 14 Dec 2017 05:43:00 +0000 Firefly: Innovative Microscope Poised to Propel Optogenetics Studies A newly developed microscope is providing scientists with a greatly enhanced tool to study how neurological disorders such as epilepsy and Alzheimer's disease affect neuron communication. The microscope is optimized to perform studies using optogenetic techniques, a relatively new technology that uses light to control and image neurons genetically modified with light-sensitive proteins. Wed, 13 Dec 2017 14:10:00 +0000 Record Revenue and Earnings: Zeiss Continues Growth Trajectory In the past 2016/17 fiscal year (ended 30 September 2017), Zeiss increased both its revenue and earnings to a record level: revenue rose by 10 percent to EUR 5.348 billion (prior year: EUR 4.881 billion). At EUR 770 million, earnings before interest and tax (EBIT) were significantly above the already high level of the previous year (615 million). The EBIT margin has increased to over 14 percent. Order intake grew by a healthy 12 percent and is now at EUR 5.625 billion, underscoring the growth ambitions of the technology company. Wed, 13 Dec 2017 13:28:00 +0000 18th ELMI Meeting: Registration Is Now Open The 18th International European Light Microscopy Initiative (ELMI) Meeting will be held in Dublin from 5th to 8th June 2018. It is a must-attend event for anyone with an active interest and involvement in leading-edge light microscopy. Wed, 13 Dec 2017 10:00:00 +0000 X-Ray Microscopy with Record Resolution Using New Multilayer Laue Lenses Scientists at DESY have developed novel lenses that enable X-ray microscopy with record resolution in the nanometre regime. Using new materials, the research team led by DESY scientist Saša Bajt from the Center for Free-Electron Laser Science (CFEL) has perfected the design of specialised X-ray optics and achieved a focus spot size with a diameter of less than ten nanometres. A nanometre is a millionths of a millimetre and is smaller than most virus particles. The researchers report their work in the journal Light: Science and Applications. Wed, 13 Dec 2017 04:42:00 +0000 Hyperlens Crystal Capable of Viewing Living Cells in Unprecedented Detail Just imagine: An optical lens so powerful that it lets you view features the size of a small virus on the surface of a living cell in its natural environment. Construction of instruments with this capability is now possible because of a fundamental advance in the quality of an optical material used in hyperlensing, a method of creating lenses that can resolve objects much smaller than the wavelength of light. Tue, 12 Dec 2017 07:31:00 +0000 Read & Win: Aberration-Corrected Analytical Electron Microscopy The book, intend for relative newcomers to the subject, is concerned with the theory, background, and practical use of transmission electron microscopes with lens correctors that can correct the effects of spherical aberration. The book also covers a comparison with aberration correction in the TEM and applications of analytical aberration corrected STEM in materials science and biology. Mon, 11 Dec 2017 14:34:00 +0000 2nd International Conference On Nanoscopy Super-resolution imaging methods now can provide spatial resolution that is well below the diffraction limit approaching virtually molecular resolution. They can be applied to biological samples and provide new and exciting views on the structural organization of cells and the dynamics of biomolecular assemblies on wide timescales. These revolutionary developments come with novel requirements for fluorescent probes, labeling techniques, and data interpretation strategies. Thu, 07 Dec 2017 05:48:00 +0000 NEUBIAS – Meeting of European BioImage Analysts Recent advancements in microscopy resulted in producing never seen volumes of images and high precision data. This created fantastic opportunities to analyze and more systematically to understand the gearing of biological systems. It also resulted in a greater need for computational resources and expertise. As a response, European scientists recently established NEUBIAS (Network of European BioImage Analysts, Cost Action CA 15124). Sat, 02 Dec 2017 05:20:00 +0000 New Nanomapping Microscope: Labelling Technique Maps DNA Mutations A team of scientists working at the University of Bristol have developed a new nanomapping microscope - powered by the laser and optics found in a typical DVD player. The new technology is being used to transform the way disease-causing genetic mutations are diagnosed and discovered. This microscope maps hundreds of chemically barcoded DNA molecules every second in a technique developed in collaboration with a team of US scientists led by Professor Jason Reed at Virginia Commonwealth University. Fri, 01 Dec 2017 08:50:00 +0000 Ultrafast Laser Streamlines MPE Microscopy Coherent´s Chameleon Discovery laser with Total Power Control is the first one-box turnkey laser for multiphoton excitation (MPE) microscopy to include built-in, high-speed power modulation. Based on the latest acousto-optic (AO) technology, this new functionality provides modulation on both the tunable femtosecond output and high power fixed output. Thu, 30 Nov 2017 12:25:00 +0000 Scanning Droplet Adhesion Microscopy: Visualizing Surface Wetting Properties The microscope is 1000 times more precise than current techniques, allowing the creation of wetting maps as a new concept for hydrophobic surface characterization. Thu, 30 Nov 2017 10:20:00 +0000 Cryo-Electron Microscopy: Revealing How Cells ‘Take Out the Trash’ Using a high-resolution imaging technique called cryo-electron microscopy (cryo-EM), scientists at The Scripps Research Institute (TSRI) have revealed how cells degrade damaged or misfolded proteins in mitochondria—cellular compartments that serve as the “powerhouses” of the cell. Thu, 30 Nov 2017 08:46:00 +0000 Inspection of Multilayer Coating in the Automotive Industry Today’s automotive industry use a variety of decorative and functional treatment to improve the vehicles surfaces. Traditional quality control methods to inspect these multilayer samples have proven to be extremely time-consuming and bear the risk of missing defects. A new approach combining a target surface system and a light microscope offers new possibilities of speed and reliability. Thu, 30 Nov 2017 04:00:00 +0000 Focus On Microscopy 2018 After the successful FOM2017 conference held in Bordeaux, France earlier this year, it is a pleasure to announce FOM2018: the next in a series of unique interdisciplinary meetings on advanced and multi-dimensional light microscopy and image processing. The conference will take place in the week before Easter from Sunday March 25  to Wednesday March 28, 2018. Wed, 29 Nov 2017 11:14:00 +0000