Imaging & Microscopy en Metafluorophores: Extremely Colorful, Incredibly Bright and Highly Multiplexed Biomedical researchers are understanding the functions of molecules within the body’s cells in ever greater detail by increasing the resolution of their microscopes. However, what’s lagging behind is their ability to simultaneously visualize the many different molecules that mediate complex molecular processes in a single snap-shot. Fri, 23 Jun 2017 05:25:00 +0000 Image Correction Software Simplifies Quantification of Stem Cells Today, tracking the development of individual cells and spotting the associated factors under the microscope is nothing unusual. However, impairments like shadows or changes in the background complicate the interpretation of data. Now, researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München have developed a software that corrects images to make hitherto hidden development steps visible. Thu, 22 Jun 2017 08:06:00 +0000 Park Systems Introduces Park NX12 for Unsurpassed Affordable High Resolution NanoScale Imaging Park Systems, world-leading manufacturer of Atomic Force Microscopes (AFM) just announced new Park NX12, an affordable versatile platform for analytical chemistry and electrochemistry researchers and multi-user facilities. Wed, 21 Jun 2017 09:20:00 +0000 Stop-Frame Filming of Chemical Reactions One of the biggest challenges of chemistry is that in a given experiment we study reactions of large ensembles of molecules (billions of billions or more) which exist in different states and possess different kinetic energies, colliding with each other in a chaotic motion. Wed, 21 Jun 2017 08:23:00 +0000 20 Years at the Forefront of Raman Imaging The Raman imaging company WITec celebrates its 20th Anniversary. It was founded in 1997 as a 3-person spin-off from the Physics Department of the University of Ulm and has grown into a company of 60 employees including the Ulm headquarters and its branch offices in Spain, China, Japan, Singapore and the USA. Wed, 21 Jun 2017 06:46:00 +0000 Powerful, Multi-Wavelength LED Illumination for All Your Fluorophores X-Cite TURBO is a powerful yet simple to use multi-wavelength LED source for fluorescence excitation applications. Providing maximum excitation via Laser LED Hybrid Drive, X-Cite TURBO offers six switchable LED wavelengths and fine intensity control with exceptional uniformity. Wed, 21 Jun 2017 06:41:00 +0000 See Clearly in True Color - Olympus BX53 Microscope Olympus’ BX53 microscope with True Color LED provides bright, sharp images in even the most challenging life science applications. The long-life LED illuminator is both brighter than a 100-watt halogen lamp and free from colour casting, producing consistently true-to-life images for longer. Tue, 20 Jun 2017 11:35:00 +0000 Raman Spectroscopy: Monitoring Biochemical Changes Following Traumatic Brain Injury Raman spectroscopy can be used to detect changes in tissue biochemistry following traumatic brain injury (TBI). Researchers examined the evolution of brain tissue composition at 2 and 7 days after traumatic brain injury. Raman spectroscopy is sensitive to changes in protein concentration and lipid composition, which are of particular interest in brain repair. Tue, 20 Jun 2017 10:24:00 +0000 X-Ray Imaging: Deciphering the Atomic Structure of an Intact Virus An international team of scientists has for the first time used an X-ray free-electron laser to unravel the structure of an intact virus particle on the atomic level. The method used dramatically reduces the amount of virus material required, while also allowing the investigations to be carried out several times faster than before. This opens up entirely new research opportunities, as the research team lead by DESY scientist Alke Meents reports in the journal Nature Methods. Mon, 19 Jun 2017 15:01:00 +0000 Higher Eigenmode Tricks in Multifrequency Atomic Force Microscopy We offer a simple explanation of the effect of the higher eigenmode’s free amplitude on probe sensitivity and indentation depth in bimodal atomic force microscopy (AFM). The explanation is based on a qualitative analysis of the cantilever’s equation of motion and offers a concrete basis for the optimization of the higher eigenmode contrast. The concepts discussed are also applicable to multifrequency AFM techniques involving more than two eigenmodes. Mon, 19 Jun 2017 13:00:00 +0000 FIB-SEM Tomography of Porous Geological Materials Focused Ion Beam (FIB) milling capabilities incorporated into a traditional Scanning Electron Microscope (SEM) constitutes a powerful tool for the observation of internal structures at high resolution in biological and materials science, as well as in industry. In recent years its use has been extended to geological samples [1–5], enabling  3D volume analysis with nano-scale resolution providing Earth scientists with unparalleled insights into the complex internal structural and chemical variations that govern the physical properties of geological materials. Mon, 19 Jun 2017 06:49:00 +0000 C-FLEX Laser Combiner HÜBNER Photonics, the youngest division of HÜBNER GmbH & Co KG, are proud to introduce a new compact and flexible laser combiner, C-FLEX. The C-FLEX laser combiner is available with up to six wavelengths from a selection of 30 wavelengths over the visible spectrum. Designed around the integration of Cobolt lasers, though accommodating lasers from most vendors, the C-FLEX offers streamlined operation via a single computer interface. Mon, 19 Jun 2017 05:53:00 +0000 Innovations by PicoQuant at Laser World of Photonics Highlights include a new green picosecond pulsed laser head, an expanded VisIR/VisUV laser platform line-up, and the FLIMbee galvo scanner add-on for the MicroTime 200 Wed, 14 Jun 2017 05:36:00 +0000 Novel High-ResolutionTechniques Examine Solar Cells with Nanoscale Precision Using two novel techniques, researchers at the National Institute of Standards and Technology (NIST) have for the first time examined, with nanometer-scale precision, the variations in chemical composition and defects of widely used solar cells. The new techniques, which investigated a common type of solar cell made of the semiconductor material cadmium telluride, promise to aid scientists in better understanding the microscopic structure of solar cells and may ultimately suggest ways to boost the efficiency at which they convert sunlight to electricity. Tue, 13 Jun 2017 05:49:00 +0000 A New High Pressure form of Ba3NiSb2O9 X-ray, neutron and electron diffraction methods are widely used for the investigation of crystals. Each of these techniques has their own advantages in terms of element sensitivity, sample size requirements etc. and are chosen accordingly for structure determinations. A less obvious difference lies in the spatial resolution of these diffraction techniques. Here, we show that electron diffraction can elucidate the local structure where X-ray and neutron diffraction only sens the average structure. Introduction Mon, 12 Jun 2017 07:52:00 +0000 Quantum Nanoscope: Seeing Electrons Surfing the Waves of Light on Graphene Researchers have studied how light can be used to “see” the quantum nature of an electronic material. They managed to do that by capturing light in a net of carbon atoms and slowing down light it down so that it moves almost as slow as the electrons in the graphene. Then something special happens: electrons and light start to move in concert, unveiling their quantum nature at such large scale that it could observed with a special type of microscope. Fri, 09 Jun 2017 12:41:00 +0000 RapidFLIM: Fast Imaging Technique Redefining the Standards for Dynamic FLIM Imaging The rapidFLIM method exploits recent advances in Time-Correlated Single Photon Counting (TCSPC) electronics, where ultra-short dead times allows for imaging fast, dynamic processes via Fluorescence Lifetime Imaging (FLIM). Thu, 01 Jun 2017 11:54:00 +0000 Camera Technology: Seeing the Invisible Over the past 40 years, microelectronics has advanced by leaps and bounds thanks to silicon and CMOS (Complementary metal-oxide semiconductors) technology, making possible computing, smartphones, compact and low-cost digital cameras, as well as most of the electronic gadgets we rely on today. However, the diversification of this platform into applications other than microcircuits and visible light cameras has been impeded by the difficulty to combine semiconductors other than silicon with CMOS. Wed, 31 May 2017 12:30:00 +0000 Correlative Microscopy: Combining STED Capability with Atomic Force Microscopy JPK Instruments, a manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, announced a new demonstration capability at their Berlin headquarters. In collaboration with Abberior Instruments, visitors to JPK's applications facility will be able to see STED capability demonstrated in conjunction with the NanoWizard AFMs. Wed, 31 May 2017 06:08:00 +0000 Using X-Ray Technique to See 3D Deformations While doctors use X-rays to see the broken bones inside our bodies, scientists have developed a new X-ray technique to see inside continuously packed nanoparticles, also known as grains, to examine deformations and dislocations that affect their properties. In a new study published in Science, researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory used an X-ray scattering technique called Bragg coherent diffraction imaging to reconstruct in 3D the size and shape of grain defects. Tue, 30 May 2017 05:48:00 +0000 Neutron Scattering Analysis: First Nanoscale Look at a Living Cell Membrane A research team from the Department of Energy’s Oak Ridge National Laboratory has performed the first-ever direct nanoscale examination of a living cell membrane. In doing so, it also resolved a long-standing debate by identifying tiny groupings of lipid molecules that are likely key to the cell’s functioning. Mon, 29 May 2017 09:22:00 +0000 Super-Resolution Microscopy: How Cells Combat Salmonella With drug resistance being on the rise worldwide, bacterial infections pose one of the greatest global threats to human health. By deciphering the host-pathogen interaction on a molecular level, researchers hope to pave the way for new therapies. Studying the cell’s reaction to Salmonella, scientists from Goethe University Frankfurt have now made a critical discovery to this respect. Wed, 24 May 2017 07:36:00 +0000 High-Resolution Microscopy: A Precise Look into the Depths of Cells Is it possible to observe how fish embryos develop into trout, carp or salmon at cell level? Researchers at the Goethe-University in Frankfurt Germany have managed to achieve this by combining a special form of fluorescence microscopy with a second microscopy technology. The new high resolution light microscope enables fascinating exploration of the interior of cells. Tue, 23 May 2017 07:17:00 +0000 Error-Free Microscopy with the Olympus CX3 Series Olympus’ CX3 series of upright microscopes enables error-free microscopy for users of all levels and experience. The new CX33 and CX43 microscopes provide maximum comfort during long periods of observation. Their unique, ergonomic design is the result of a deep analysis of the clinical microscopy workflow, in which every single daily movement is taken into account. The CX23 is instead a robust and cost-effective microscope dedicated to microscopy education. Fri, 19 May 2017 08:19:00 +0000 Cobolt Skyra: The New Multi-Line Laser Cobolt AB, Swedish manufacturer of high performance lasers, proudly introduces the Cobolt Skyra, a revolutionary multi-line laser platform. Offering up to 4 laser lines in a box that can fit into the palm of your hand (70 x 134 x 38 mm) and requiring no external electronics, the Cobolt Skyra will enable the next generation of compact and easy-to-use analytical instrumentation for the life science market. Fri, 19 May 2017 07:46:00 +0000