Imaging & Microscopy en ASI’s Dual Inverted Selective Plane Illumination Microscopy (diSPIM) ASI’s diSPIM system is an extremely cell friendly for imaging live specimens. It only illuminates the region of the specimen that is being viewed, reducing phototoxicity and reducing photobleaching  ~7-10 fold. Unlike other SPIM systems, the diSPIM allows the use of conventional mounting and glass coverslips. Wed, 23 Aug 2017 23:06:00 +0000 Super-Photostable Fluorescent Labeling Agent for Super-Resolution Microscopy Chemists at ITbM, Nagoya University have developed a super-photostable fluorescent dye, PhoxBright 430 (PB430), to visualize cellular ultrastructure by super resolution microscopy. The exceptional photostability of this new dye enables continuous STED imaging and together with its ability to fluorescently label proteins, PB430 demonstrates its use in the 3D construction and multicolor imaging of biological structures. Mon, 21 Aug 2017 06:29:00 +0000 Redefining the Standard for Ultra Fast FLIM Imaging: rapidFLIM The novel rapidFLIM approach allows acquiring fluorescence lifetime images at high speeds by exploiting recent hardware developments.Depending on image size and sample brightness, more than 15 images can be acquired per second, allowing investigating dynamic processes such as protein interaction and chemical reactions, investigating Thu, 17 Aug 2017 07:32:00 +0000 Imaging Tiny Quasicrystals as They Form When Israeli scientist Daniel Shechtman first saw a quasicrystal through his microscope in 1982, he reportedly thought to himself, “Eyn chaya kazo” – Hebrew for, “There can be no such creature.” But there is, and the quasicrystal has become a subject of much research in the 35 years since Shechtman’s Nobel Prize-winning discovery. What makes quasicrystals so interesting? Thu, 17 Aug 2017 07:07:00 +0000 Improving Lensless Computational Microscopy Technology Scientists from ITMO University and the Tampere University of Technology have improved upon a method for computational processing of optical signals in lensless microscopes. The algorithms they developed have helped increase the resolution of images acquired from such microscopes. Results of their research have been published in The Optical Society’s (OSA) scientific journal Optica. Computational Imaging and Lensless Microscopy Wed, 16 Aug 2017 10:58:00 +0000 Olympus Image of the Year Award Olympus is celebrating art in science with a competition to find the best light microscopy images taken in the EMEA region this year. For the chance to win a microscope, applicants can simply submit their best life science light microscopy images taken with Olympus equipment to the campaign website. Mon, 07 Aug 2017 08:38:00 +0000 WITec’s RISE Correlative Microscopy is Now Available with ZEISS SEM Systems The WITec RISE microscopy mode for correlative Raman-SEM imaging is now compatible with Zeiss Sigma 300, a field emission scanning electron microscope (FE-SEM). With this jointly-developed hybrid system, WITec and Zeiss have furthered their collaboration to provide a fully-integrated instrument available as an OEM product through Zeiss that features a standard, unmodified vacuum chamber and SEM column along with a complete confocal Raman microscope and spectrometer. Mon, 07 Aug 2017 08:08:00 +0000 Merging Expansion Microscopy and Structured Illumination Reveals 3D Structure of Protein Complex Researchers at the Stowers Institute for Medical Research have solved the three-dimensional structure of a complex that is essential for the correct sorting of chromosomes into eggs and sperm during reproductive cell division or meiosis. When this structure, called the synaptonemal complex, doesn't assemble properly in the cell, it can lead to chromosomal abnormalities, miscarriages, and birth defects. Fri, 04 Aug 2017 07:33:00 +0000 Discrete Molecular Imaging: From Super-to Ultra Resolution Microscopy Andor Technology has reported that their iXon and Zyla cameras helps drive microscopy from super to ultra-resolution. Scientists at Harvard University’s Wyss Institute for Biologically Inspired Engineering have demonstrated an optical resolution of less than five nanometres (<5 nm) by using a new method called Discrete Molecular Imaging (DMI). Thu, 03 Aug 2017 05:12:00 +0000 High-Speed FM-AFM: Atomistic Dissolution Processes of Calcite in Water Researchers have developed high-speed frequency modulation AFM (FM-AFM) and enabled atomic-resolution imaging in liquid at ∼1 s/frame. With this AFM, the scientists have obtained images revealing the transition region is formed along the step edges. The simulations suggest the transition region be a Ca(OH)2 monolayer formed as an intermediate state. Thus, our understanding of the calcite dissolution in water is much improved. This FM-AFM will be applicable to various studies on solid−liquid interface dynamic processes. Tue, 01 Aug 2017 10:43:00 +0000 ITO Coating for Correlative Microscopy Correlative microscopy of immunolabeled cells performed by scanning electron and light microscopy needs a suitable coating. It aims at making the sample surface conductive without masking the backscattered electrons emitted by the high atomic number immunolabeling nanoparticles. Indium-tin oxide (ITO) has been revealed as an effective coating material, being it conductive, stable against oxidation over time and with mean atomic number low enough to not mask the backscattered electrons signal. CLEM Imaging of Cells Sun, 30 Jul 2017 12:36:00 +0000 Nano Innovation Award 2017 for Junior Nanoscientists On July 21, the Nano Innovation Awards were awarded at the Center for Nanoscience (LMU Munich). For the first time, candidates from all over Bavaria were invited to apply for the awards worth € 9.000. Three PhD students and one Master student from Würzburg and Munich won prizes for their innovative work in application-oriented nanoscience. Since many years, attocube is one of the sponsors of the Award. Thu, 27 Jul 2017 10:26:00 +0000 Super-Resolution Microscope: Microscale Lens Realizes Nanoscale Imaging A*STAR researchers and collaborators at the National University of Singapore have developed a non-invasive optical microscope that can image smaller objects than conventional microscopes, and does not require samples to be dyed. Thu, 27 Jul 2017 08:31:00 +0000 Seeing is Believing - Imaging the Processes of Life The processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across this full scale of biological organisation is revolutionising our ability to visualise the inner workings of proteins, protein complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanism of life as well as disease. Aims Wed, 26 Jul 2017 08:03:00 +0000 Molecular Microscopy Illuminates Molecular Motor Motion A toddler running sometimes loses footing because both feet come off the ground at the same time. Kinesin motors that move materials around in cells have the same problem, which limits how fast they can traverse a microtubule in the cell and carry cargo, according to Penn State researchers who have now seen these kinesin motors move using an unusual microscope and tagging method. Wed, 26 Jul 2017 06:54:00 +0000 Zeiss CEO Kaschke Confirmed until 2020 The Supervisory Board of Carl Zeiss AG has decided to continue the appointment of Dr. Michael Kaschke as President & CEO until 30 June 2020. Kaschke joined the Zeiss Group 25 years ago and has served on the Executive Board since 2000. He has been President & CEO of Carl Zeiss since 2011. Tue, 25 Jul 2017 07:42:00 +0000 3D Imaging of Surface Chemistry in Confinement EPFL researchers have developed an optical imaging tool to visualize surface chemistry in real time. They imaged the interfacial chemistry in the microscopically confined geometry of a simple glass micro-capillary. The glass is covered with hydroxyl (-OH) groups that can lose a proton – a much-studied chemical reaction that is important in geology, chemistry and technology. A 100-micron long capillary displayed a remarkable spread in surface OH bond dissociation constant of a factor of a billion. The research has been published in Science. Fri, 21 Jul 2017 06:34:00 +0000 Improving Super-Resolution Imaging with Nanoparticle ‘Buckyswitch’ Visualizing biological cells under a microscope was just made clearer, thanks to research conducted by graduate student Yifei Jiang and principal investigator Jason McNeill of Clemson University’s department of chemistry. Wed, 19 Jul 2017 13:10:00 +0000 Preparation and Loading of Nanopipettes The workgroup "Biomolecular Photonics" at Bielefeld University, Germany, has been using nanopipettes now for over a decade, representing key elements for scanning ion conductance microscopy (SICM), nanoinjection and nanodeposition. As essential parts for these applications, nanopipettes mediate an ionic current through liquid solution loaded inside the hollow nanopipettes and leading it through their tip aperture with diameters from 100 nm down to 10 nm. Tue, 18 Jul 2017 07:19:00 +0000 Raman Imaging: Watching Molecular Dynamics Involved in Neurodegenerative Diseases Researchers have developed a fast and practical molecular-scale imaging technique that could let scientists view never-before-seen dynamics of biological processes involved in neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis. Tue, 18 Jul 2017 06:01:00 +0000 Improved Imaging of Live Cells with New Dyes Radiation in the near-infrared region is invisible, but can deeply penetrate living tissue without damaging it. Dye molecules that produce near-infrared light consequently have valuable applications in medical diagnostics, and A*STAR researchers have developed a synthetic approach that can quickly identify ways to fine-tune their emission properties. Mon, 17 Jul 2017 11:59:00 +0000 The Nanoworld in 3D The world is round, and so are cells; and like our planet cells have a geometry in three dimensions. However, for many years this fact was often overlooked in electron microscopy because it was technically difficult to image cells in 3D. Now three new techniques (serial block face imaging, focused ion beam-SEM and array tomography) have emerged that bring the third dimension to imaging at the nanoscale. Mon, 10 Jul 2017 08:05:00 +0000 Andor´s iXon SRRF-Stream: Super-Resolution Microscopy Camera Andor Technology has introduced SRRF-Stream, a real time super-resolution microscopy functionality that operates on iXon EMCCD cameras. It unlocks real time super resolution fluorescence microscopy on most modern microscopes, using conventional fluorophores at low illumination intensities, thus making it highly compatible with live cell imaging. Fri, 07 Jul 2017 11:20:00 +0000 Don Riddell joins NKT Photonics as Chief Operating Officer NKT Photonics has appointed Don Riddell as Chief Operating Officer (COO). Don will take up the responsibility of managing NKT´s three manufacturing sites in Denmark, the UK and Germany. Thu, 06 Jul 2017 14:08:00 +0000 NKT Photonics to acquire Onefive NKT Photonics has entered into an agreement to acquire Onefive, a leading ultrafast laser manufacturer headquartered in Zurich, Switzerland. The acquisition will strengthen NKT Photonics’ Material Processing business by adding complementary know-how and products to the portfolio. Thu, 06 Jul 2017 12:42:00 +0000