Imaging & Microscopy en Measuring the Size Distribution of Nanomaterials FRAP is widely applicable in the biophysical, pharmaceutical and material sciences to study diffusion of molecules and nanoparticles on a micrometer scale. Here we extend the capability of FRAP to measuring polydisperse samples with a continuous distribution of diffusion coefficients (cFRAP). We demonstrate that cFRAP is a new analytical technique that allows to measure the size distribution of polydisperse nanomaterials, not only in buffer solutions but also in biological fluids. Introduction Fri, 16 Mar 2018 05:32:00 +0000 Leica EM TIC3X – Ion Beam Slope Cutter The Triple Ion Beam Milling System, Leica EM TIC 3X allows production of cross sections and planed surfaces for Scanning Electron Microscopy (SEM), Microstructure Analysis (EDS, WDS, Auger, EBSD) and, AFM investigations. Thu, 15 Mar 2018 10:21:00 +0000 Leica EM TXP – Target Surfacing System The Leica EM TXP is a target preparation device for milling, sawing, grinding, and polishing samples prior to examination by SEM, TEM, and LM techniques. An integrated stereomicroscope allows pinpointing and easy preparation of barely visible targets. Thu, 15 Mar 2018 10:16:00 +0000 Leica EM UC7/FC7 – Ultramicrotome for Room Temperature and Cryo Sectioning High quality sectioning of specimens for light, electron, and atomic force microscopy examination has never been easier and more precise. Leica Microsystems introduces its latest specimen preparation technology: the Leica EM UC7 ultramicrotome and the Leica EM FC7 cryo chamber attachment. Wed, 14 Mar 2018 08:48:00 +0000 From Electron Microscopy to 3D Printing The exhibition “Fungi – Food, Poison and Mythology” in the Museum Wiesbaden, Germany shows more than 1300 fungi models. As a special highlight macroscopic 3D reconstructions of spores are presented which have their origin in serial block-face scanning electron microscopy. This method was applied to embedded spores with diameters of some microns. Computer based 3D reconstructions, 3D printing and the production of hollow casts lead to 126 impressive objects featuring a magnification of about 20.000x. Mon, 12 Mar 2018 05:18:00 +0000 Quasi-epitaxial Growth of [Ru(bpy)3]2+ by Confinement in Clay Nanoplatelets Yields Polarized Emission Cryogenic ion etched biosamples were prepared by Leica Microsystems to support research on polarized emission by orientation of photoluminescent organic molecules. In this article, the authors present a nano confinement strategy to control the spatial orientation and emission polarization of phosphorescent metal complexes. Click here to read the full text article. Fri, 09 Mar 2018 09:13:00 +0000 The effect of magnesium on the corrosion of hot‐dip galvanized steel in chloride containing environments In this article published in Materials and Corrosion 65. No. 9, T. A. Keppert et al. report on the testing of three different hot-dip galvanizing alloys in salt spray tests. A Leica EM TIC 3X was used to polish cuts of metallographic cross-sections for EDX analysis of areas of interest. Click here to read the full text article. Fri, 09 Mar 2018 08:40:00 +0000 Role of Phase Morphology on the Damage Initiated Self-healing Behavior of Ionomer Blends Self-healing materials based on polymer blends made of ionomers are interesting materials from both scientific and technological point of view. The self-healing behaviors of such materials were investigated by Mohammed Arifur Rahman et al. For the research reported in this article, the authors used a Leica EM UC7 ultramicrotome with an EM FC7 cryo chamber for preparation of the specimens for TEM analysis. Click here to read the full text article Fri, 09 Mar 2018 07:38:00 +0000 Inspection of Multilayer Coating in the Automotive Industry F. Javier Ruiz Balbas, Laboratory Manager of the Quality Control Department at Atotech Spain, has changed his workflow from traditional quality control methods to a new approach combining the Leica EM TXP target surfacing system and the Leica DM2700 M light microscope. In the article “Inspection of Multilayer Coating in the Automotive Industry” he describes his experience with the system. Fri, 09 Mar 2018 06:00:00 +0000 Super-Resolution Microscopy: A New, Short and Inert Tagging Strategy for dSTORM Imaging To make cellular structures easily accessible for super-resolution microscopy, scientists at the Max Planck Institute for Terrestrial Microbiology in Marburg, the Natural and Medical Sciences Institute (NMI) in Reutlingen and the Eberhard Karls University of Tübingen have developed a new strategy for dense, unobtrusive labeling of proteins. Thu, 08 Mar 2018 13:00:00 +0000 Combining Spectroscopy with High-Resolution Microscopy to See the Quantum World JILA scientists have invented a new imaging technique that produces rapid, precise measurements of quantum behavior in an atomic clock in the form of near-instant visual art. The technique combines spectroscopy, which extracts information from interactions between light and matter, with high-resolution microscopy. Tue, 06 Mar 2018 09:34:00 +0000 Imaging the Brain with Synthetic Bioluminescence Glowing creatures like fireflies and jellyfish are captivating to look at but also a boon for science, as their bioluminescent molecules contribute to visualizing a host of biological processes. Now, scientists in Japan have supercharged these molecules, making them hundreds of times brighter in deep tissues and allowing for imaging of cells from outside the body. The bioengineered light source was used to track cancer cells in mice and brain-cell activity in monkeys, but its applications extend beyond the lab. Fri, 02 Mar 2018 11:46:00 +0000 Need for Speed Chemical fixation followed by epon embedding and thin sectioning still is a powerful approach for the ultrastructural analysis of a wide variety of biological and clinical samples. To achieve good preservation, most protocols, however, are labour intensive and time-consuming, usually taking 3-4 days. Here, we describe alternative approaches that provide samples with reasonable ultrastructural preservation and tissue contrast within one day, using either a microwave-assisted procedure or a protocol with reduced incubation times. Fri, 02 Mar 2018 05:17:00 +0000 Megapixel Scanning Laser Vibrometer from SmarAct Vibrations play a decisive role in the performance of mechanical structures. This also includes the field of microelectromechanical systems (MEMS). Thu, 01 Mar 2018 13:12:00 +0000 DNA Origami: How Exact is my Nanoruler? The development and evaluation of DNA origami-based nanorulers enables measurements in the nano cosmos with increasing precision. NIM scientist Prof Dr Philip Tinnefeld and his team explore such self-assembled nano structures. To measure distances in our daily life, normally we utilze rulers or a folding ruler. Quantification takes place by comparing the object or distance and the ruler. Thu, 01 Mar 2018 10:48:00 +0000 Metastasis: Cell Polarity Matters Not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the German Cancer Research Center (DKFZ) have now reported. For circulating cancer cells to be able to invade tissues and settle at other sites in the body, they have to exhibit a specific polarity. This discovery might in future help to better predict individual risk for metastasis and find appropriate therapies that can reduce it. Thu, 01 Mar 2018 09:28:00 +0000 4D Cell Microscopy: Super-Resolution in Both Space and Time In a breakthrough for biological imaging, EPFL scientists have developed the first microscope platform that can perform super-resolution spatial and temporal imaging, capturing unprecedented views inside living cells. The landmark paper is published in Nature Photonics. Wed, 28 Feb 2018 14:23:00 +0000 Combining Metalens with an Artificial Muscle Inspired by the human eye, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed an adaptive metalens, that is essentially a flat, electronically controlled artificial eye. The adaptive metalens simultaneously controls for three of the major contributors to blurry images: focus, astigmatism, and image shift. The research is published in Science Advances. Wed, 28 Feb 2018 06:11:00 +0000 Cryo-Electron Microscopy: High-Resolution Glimpse of Enzyme Structure Using a state-of-the-art type of electron microscopy, an MIT-led team has discovered the structure of an enzyme that is crucial for maintaining an adequate supply of DNA building blocks in human cells. Their new structure also reveals the likely mechanism for how cells regulate the enzyme, known as ribonucleotide reductase (RNR). Significantly, the mechanism appears to differ from that of the bacterial version of the enzyme, suggesting that it could be possible to design antibiotics that selectively block the bacterial enzyme. Tue, 27 Feb 2018 14:45:00 +0000 Lens Technology: MEMS Chips Get Metalenses Lens technologies have advanced across all scales, from digital cameras and high bandwidth in fiber optics to the LIGO lab instruments. Now, a new lens technology that could be produced using standard computer-chip technology is emerging and could replace the bulky layers and complex geometries of traditional curved lenses. Thu, 22 Feb 2018 11:51:00 +0000 Bringing High Resolution Magnetic Resonance Imaging to Nanometer Scale A new technique that brings magnetic resonance imaging to the nanometer scale with unprecedented resolution will open the door for major advances in understanding new materials, virus particles and proteins that cause diseases like Parkinson’s and Alzheimer’s. Thu, 22 Feb 2018 11:36:00 +0000 Flexible Warped Nanographene Developed for Bioimaging An international team of scientists has developed a water-soluble "warped nanographene", a flexible molecule that is biocompatible and shows promise for fluorescent cell imaging. The new nanographene molecule also induces cell death when exposed to blue laser light. Further investigation is required to determine how nanocarbons could be used for a range of biological applications, such as photodynamic therapy for cancer treatments. Wed, 21 Feb 2018 10:29:00 +0000 Engage Professional Communities Around the World with Trusted, Authoritative Content In the knowledge economy, engaging content is the key to success. Working collaboratively, we help you reach, engage and connect with your audiences via credible content. As the B2B arm of Wiley, we provide access to extensive communities including key opinion leaders, enabling you to effectively deliver your message and shape your market. Wed, 21 Feb 2018 09:23:00 +0000 KEY Award for New Faculty Once again, Nightsea, developers of the  stereo microscope fluorescence adapter (SFA), and EMS, industry supplier of laboratory accessories, are teaming up to offer the KEY Award: a special grant to help first-year faculty members add fluorescence stereo microscopy to their new laboratories. Wed, 21 Feb 2018 07:41:00 +0000 Olympus´ IXplore SpinSR - See more with Live-Cell Super Resolution Olympus’ latest addition to the IXplore series, the IXplore SpinSR, combines super resolution, confocal and widefield imaging in one easy-to-use system with fast switching between imaging modes. Fri, 16 Feb 2018 12:00:00 +0000