Nov. 03, 2009
The appearance of hair is influenced by the 3D geometric arrangement of hair fibres. An accurate 3D representation of hair is needed for hair research to assess the effect of different treatments. X-ray microtomography (XRT) can be used for the 3D visualisation of hair arrays and the quantitative analysis of volume and shape attributes.
Introduction moreNov. 03, 2009
Modern optical microscopy has always represented an indispensable tool for biomedical research. One of the most relevant and successful transformations of the modern microscope is the ability to parallel an instrumental modification with the development of new assays for the determination of functional parameters. Instrument performances have been consequently optimized for the analysis of extremely heterogeneous targets, ranging from single molecules up to living organisms. moreNov. 03, 2009
Supernumerary or extra teeth also result from disturbances during the initiation and proliferation stages of dental development. The most common supernumerary tooth appears in the maxillary midline and is called a mesiodens. The maxillary midline is the most common location for a supernumerary tooth, which can be almost any shape.
Introduction moreNov. 03, 2009
Imaging of single DNA molecules has reached the best spatial resolution by means of dynamic force mode. Amplitude and Frequency Modulation modes at room and low temperature in UHV indicate semi-contact or non-contact as the best modes to achieve high resolution on such small biological molecules. A step forward to more quantitative results is single point force spectroscopy. The force and potential evaluation from the experimental curves evidences the contrast between substrate and DNA and suggests the Non Contact AFM as a possible tool for molecular recognition. moreNov. 03, 2009
Ever since the first human embryonic stem cell line was established, hopes have been raised that treatment for a wide range of cellular degenerative disease and injuries is imminent. While significant progress has been made in stem cell research in recent years, several hurdles remain to be overcome before stem cells can be used routinely in the clinic. In particular, the understanding of the mechanisms that control cell integration, differentiation and proliferation in recipient tissues is far from complete. moreNov. 03, 2009
In this article we discuss the ability of optical tweezers to both trap and probe airbrone particles. We highlight that a number of optical trapping techniques such as holographic optical tweezers and dual beam traps are possible and may open up new ways to analyse aerosols, for atmospheric studies. We show that both liquid and solid aerosols can be trapped and that even broadband laser sources such as a supercontinuum may be used to trap particles and can probe properties such as evaporation. moreNov. 03, 2009
An efficient receptor-mediated delivery system has been developed using preformed complexes of Quantum Dots (QDs) and the Epidermal Growth Factor (EGF) ligand. Liposomes are either loaded or surface modified combining two colors of QDs probes. The dual labeling strategies involve only biotin-streptavidin interactions and do not require further purification from free QDs-EGF. moreNov. 03, 2009
Fluorescence microscopy has become the method of choice in the majority of life-science applications. However, standard fluorophores do not luminesce brightly enough for some applications. We describe development and use of mirror slides to significantly enhance the fluorescence signal using standard air microscope objectives. This technique offers sufficient gain to achieve high-sensitivity imaging, together with a wide field of observation and a large depth of focus. more