Science
Imaging Motile Malaria Parasites
How an Ancient Eukaryote can Serve as a Motile Model Cell
Nov. 02, 2011
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Fig. 1: (A) Cartoon of the malaria parasite life cycle. The parasite causes disease in the blood, ... more
![Fig. 2: (A) Cartoon (top) and rendered tomogram (right) of the Plasmodium sporozoite [10]. Note the ...](/sites/imaging-git.com/files/images/special/4568603_minimal.jpg "Fig. 2: (A) Cartoon (top) and rendered tomogram (right) of the Plasmodium sporozoite [10]. Note the microtubule basket (green) at the front end of the sporozoite that encircles specialized secretory vesicles (magenta and cyan), the nucleus at the rear and the chloroplast-like apicoplast (yellow). A further blow-up (grey) shows a schematized drawing of selected proteins that play a role in sporozoite motility, the plasma membrane proteins TRAP, TLP, S6, the cytoplasmic aldolase and actin as well as the myosin, which is anchored to the inner membrane complex (IMC, shown in yellow in the rendered tomogram), a specialized organelle subtending the entire plasma membrane. (B) DIC images of the rodent malaria model organism Plasmodium berghei moving in circles on glass. Time is indicated in seconds. Scale bar: 10 µm. (C) Fluorescent images of motile P. berghei sporozoites expressing the green fluorescent protein in their cytoplasm. Three subsequent images are colored red, green and blue to highlight different movements (insets) [1]."){kind=small}
Authors
Dr. Friedrich Frischknecht
Janina Kristin Hellmann
Mirko Singer
University of Heidelberg Medical School
Parasitology, Department of Infectious Diseases
Heidelberg, Germany
www.klinikum.uni-heidelberg.de
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Keywords: Cell Motility Friedrich Frischknecht Imaging Light Microscopy Malaria Parasitology Plasmodium Plasmodium berghei Sporozoites TRAP Protein Family
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