09.02.2010

Routine Assessment of Fluorescence Microscope Performance

Modern automated fluorescence microscopes are complex devices, dedicated to produce accurate representations of objects at a resolution exceeding the resolving power of the human visual system up to about 1000-fold. The fidelity and efficiency of this imaging process critically depends on the accurate ensemble performance of various optic and electronic devices. more09.11.2009

Correlative Video-Light-Electron Microscopy

Microscopical studies in biology have relied on two complementary microscope technologies - light (fluorescence) microscopy and electron microscopy. Light microscopy is used to study phenomena at a global scale and to look for unique or rare events, and it also provides an opportunity for live imaging, while the forte of electron microscopy is the high resolution. Observation of living cells under EM is still impossible. Traditionally light and electron microscopy (EM) observations are carried out in different populations of cells/tissues. more