Apr. 14, 2014
Atomic force microscopy (AFM) has become a promising tool for manipulating nano-objects to fabricate nano-structures or nano-devices. However, there are still some challenges facing the development of an AFM based robotic nanomanipulation system, such as the uncertainties associated with AFM tip and nanoparticles, the single point force and interaction between the tip and nanoparticles, and the parameter calibration of models being used. This work was published in IEEE Nanotechnology Magazine.
moreApr. 11, 2014
An AFM probe is a cantilever, shaped like a tiny diving board with a small, atomic-scale point on the free end. To measure forces at the molecular scale in a liquid, the probe attaches its tip to a molecule such as a protein and pulls; the resulting deflection of the cantilever is measured. The forces are in the realm of piconewtons, or trillionths of a newton. One newton is roughly the weight of a small apple. The new probe design, described in ACS Nano, is the JILA research group's third recent advance in AFM technology.
moreMar. 20, 2014
blueDrive for Asylum Research Cypher AFMs has reinvented tapping mode for more simple, stable and accurate imaging, especially for biological samples that are typically imaged in fluid. blueDrive replaces the conventional piezoacoustic excitation mechanism and uses a blue laser to directly excite the AFM cantilever photothermally.
moreMar. 19, 2014
Horiba Scientific has introduced the XploRA PLUS Raman microscope. XploRA PLUS incorporates unique and powerful research functions in an impressively compact analytical bench footprint.
Offering simplicity, reliability and power, it does not compromise data quality or image resolution. XploRA PLUS is a fully confocal and high performance Raman microscope, offering an unmatched and enhanced range of options such as multiple laser wavelengths, complete automation, EMCCD detection, Raman polarization and even AFM coupling.
moreMar. 19, 2014
Even the mildest form of a traumatic brain injury, better known as a concussion, can deal permanent, irreparable damage. Now, an interdisciplinary team of researchers at the University of Pennsylvania is using mathematical modeling to better understand the mechanisms at play in this kind of injury, with an eye toward protecting the brain from its long-term consequences.
moreMar. 14, 2014
Since its invention Atomic Force Microscopy has established itself as a versatile tool for imaging material systems & associated dynamic processes. In the early 90s the technique was further developed to incorporate the use of heated probes as means of scanning the sample surface. In this study E.coli bacterial cells were used in an attempt to not only further develop and optimize the use of thermal AFM, but also to try and gain further insight into their interactions with pharmaceutical materials.
moreMar. 10, 2014
In collaboration with colleagues from Berlin and Madrid, researchers at the Department of Physics at the University of Basel have pulled up isolated molecular chains from a gold surface, using the tip of an atomic force microscope (AFM). The observed signal provides insight into the detachment force and binding energy of molecules. The results have been published in the journal PNAS.
moreMar. 06, 2014
Asylum Research, an Oxford Instruments company, invites all Cypher and MFP-3D AFM users to enter their best AFM data, including images, force curves, or videos, in the Asylum Research Image Contest. Each scientist will receive an Asylum gift pack just for sending in their images. An Apple iPad will be awarded at the close of each quarter to the winning image that best represents excellence in science and the "cool" factor as judged by our team of applications scientists. Select entries will also be featured in the Asylum Research website gallery.
moreFeb. 25, 2014
The lipid bilayer rupture was here explored by means of AFM-based force clamp. For the first time to our knowledge, this technique has been used to evaluate how lipid membranes respond when compressed under an external constant force in the range of nN. We were able to directly quantify the kinetics of the membrane rupture event and the associated energy barriers, in distinction to the classic studies performed at constant velocity.
moreFeb. 10, 2014
Leading papers from the 5th AFMBiomed Conference on AFM in Life Sciences and Medicine are published as the first virtual issue within Journal of Molecular Recognition. The issue is free to access until the end of March.