Sep. 20, 2013
Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease. Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics (FiO), The Optical Society's (OSA) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and fluids within tumors; examine abnormalities in the blood vessel network inside them; and observe how the tumors were affected by treatments.
moreMay. 16, 2013
Confocal laser scanning microscopy (CLSM) is a powerful tool, advancing research across a variety of disciplines. With the many challenges faced by the pharmaceutical industry, ensuring a drug reaches its target site is a key priority. This article describes how CLSM is central to the development of a novel drug delivery system, where the authors have created an advanced stealth liposome approach.
moreDec. 19, 2012
FEI Company has released a correlative microscopy solution set for light and electron microscopy (CLEM). By combining imaging techniques and efficient workflows, cell biologists could gain a better understanding of the structure and function of cells to improve the treatment of diseases, such as cancer, AIDS, and Parkinson's.
moreMar. 01, 2012
Skin Cancer Screening: Intense episodes of UV exposure can contribute to malignant melanoma (MM), the most dangerous type of skin cancer. The UV exposure originates in the pigment-producing melanocytes in the basal layer of the epidermis. Early detection and complete excision of the primary lesions is crucial for reducing melanoma-related deaths but current diagnostic practice is highly subjective. This leads to unnecessary surgical procedures, which are highly-invasive and expensive.
moreFeb. 01, 2011
Patricia Barral and her colleagues study the cellular and molecular mechanisms controlling lymphocyte activation and eventual fate. Knowledge of these processes is invaluable not only in increasing our understanding of the causes of cancer but also in the treatment and prevention of infectious and autoimmune diseases. The Lymphocyte Interaction Laboratory was the first team to establish a role for a group of macrophages in acquiring antigen and presenting intact antigen to follicular B cells in lymph nodes in vivo.
moreNov. 30, 2010
The long, anxious wait for biopsy results could soon be over, thanks to a tissue-imaging technique developed at the University of Illinois. The research team demonstrated the novel microscopy technique, called nonlinear interferometric vibrational imaging (NIVI), on rat breast-cancer cells and tissues. It produced easy-to-read, color-coded images of tissue, outlining clear tumor boundaries, with more than 99 % confidence - in less than five minutes.
moreNov. 03, 2010
It sounds like an idea plucked from the realms of science fiction writing. But in this case, there is nothing fictional about it. Scientists in Yorkshire have developed a process that uses the luminous cells from jellyfish to diagnose cancers deep within the human body. The method has been developed at the Yorkshire Cancer Research Laboratory at The University of York and the man who leads the York team, Professor Norman Maitland, believes it will revolutionize the way some cancers are diagnosed.
moreJul. 05, 2010
Fluorescence microscopy combines the power of high performance optical components and digital image analysis. The emission signals of fluorescent dyes show a significant spectral crosstalk which inevitably increases with the number of fluorescent dyes used. However, it is possible to significantly reduce the effects of spectral crosstalk by the application of spectral imaging and spectral unmixing techniques. Spectral imaging is the combination of computer vision and spectroscopy.
Epidemiology of Breast Cancer
moreMar. 19, 2010
Promega and TOP (Transgenic Operative Products) have combined their industry technologies to provide the sensitive tools for monitoring apoptosis in live mammals, an important biomarker in cancer studies. Under the agreement, the two companies are promoting the VivoGlo Caspase 3/7 Substrate for use with transgenic repTOPTM reporter mice. The tools allow the direct visualization and quantification of apoptosis non-invasively in live mice.
moreNov. 04, 2009
Normal and diseased tissues are complex mixtures of different cell populations. A better understanding of protein expression changes that occur during
diseases needs sensitive and specific technologies for each of these cell types. Mass spectrometry based tissue imaging (MALDI-MSI) is a newly developed technique, allowing the visualization of proteins, peptides, lipids and small molecules directly on thin sections cut from fresh frozen or fixed paraffin embedded tissues.