May. 13, 2013

Unmask the Hidden without Probes: CARS

Fluorescence microscopy assumed a pivotal role in cell biology once it was possible to stain cell components selectively by fluorescing dyes. One of the first explorers of targeted stainings, Paul Ehrlich, had the idea that something that stains specifically should also kill specifically - which was associated with the term "magic bullet", the essential idea of chemotherapy. His group discovered Salvarsan, a tailored drug against syphilis - though not specific enough not to cause substantial side effects. moreDec. 03, 2012

Broadband CARS Microscopy: Imaging the Molecular Structure of Polymer Blends

Using an enhanced form of "chemical microscopy" developed at the National Institute of Standards and Technology (NIST), researchers there have shown that they can peer into the structure of blended polymers, resolving details of the molecular arrangement at sub-micrometer levels. The capability has important implications for the design of industrially important polymers like the polyethylene blends used to repair aging waterlines.
moreApr. 17, 2012

Newport’s WEU-02 Wavelength Extension Unit for Multimodal Imaging

Newport's WEU-02 wavelength extension unit is designed to expand the capability of femtosecond lasers. Through a series of user controls, the WEU-02 can be configured for use in various spectroscopy, imaging, and pump-probe applications. It can also be integrated into two-photon microscope set-ups to add modalities for enhanced imaging capabilities. moreFeb. 16, 2012

Leica TCS CARS: First Confocal System With CARS Imaging

Leica Microsystems and APE, Berlin have developed a fully integrated confocal system with the capability for CARS (Coherent Anti-Stokes Raman Scattering) imaging, the Leica TCS CARS.
The microscope system is based on the Leica TCS SP5 II and benefits from imaging at video rate and a resolution of 8 x 8 Mpx for morphological studies. moreOct. 18, 2011

Spectra-Physics Pioneers New Ultrafast Laser for Deep Tissue Imaging

Based on a novel proprietary technology, the InSight DeepSee delivers nearly double the tuning range of existing ultrafast lasers and provides seamless access to long infrared wavelengths for deepest in vivo imaging, taking multiphoton imaging to new depths. moreJun. 10, 2011

Using Nanosecond Laser Pulses to Image Plaques Lining Arteries in 3D

Ji-Xin Cheng, associate professor of biomedical engineering and chemistry at Purdue University, and his research group have developed a new type of imaging technology to take precise three-dimensional images of plaques lining arteries. moreNov. 01, 2007

3-D Imaging of Liquid Crystals by CARS Microscopy

3-D Imaging of Liquid Crystals by CARS Microscopy. B.G. Saar & colleagues used Coherent anti-Stokes Raman scattering (CARS) microscopy to provide three-dimensional chemical maps of liquid crystalline samples without the use of external labels. CARS is an optical imaging technique that derives contrast from Raman-active molecular vibrations in the sample, that offers more rapid chemical characterization without the use of external dyes or contrast agents. moreApr. 01, 2007

Focus on Microscopy 2007: Advanced Light Microscopy Community in Valencia

Focus on Microscopy 2007: Advanced Light Microscopy Community in Valencia - Which weather would you expect when you plan to visit the province of Valencia in April: sunshine all day and comfortable temperatures, of course. The condition the conferees faced at their arrival in Valencia was completely different: a cloudy sky with a good chance of showers! In contrast to this little disappointing welcome weather, this years' Focus on Microscopy conference was again a big event. more