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confocal microscopy

It´s a Small World
Jul. 14, 2014

It´s a Small World

Widefield fluorescence, confocal, and multiphoton microscopy push the boundaries of knowledge. Current capabilities of fluorescence microscopy are enabled by the availability of accurate mechanical components, many detector options, diverse light sources, precise optical filters, and high-quality objective lenses. Today's researchers are leveraging advances in components to improve microscopy.
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WITec and Tescan Introduce RISE Microscopy
Mar. 28, 2014

WITec and Tescan Introduce RISE Microscopy

WITec and Tescan have introduced RISE Microscopy, a correlative microscopy technique which combines confocal Raman Imaging and Scanning Electron (RISE) Microscopy within one integrated microscope system. more
RISE Microscopy
Mar. 27, 2014

RISE Microscopy

RISE Microscopy is a novel correlative microscopy technique that combines Scanning Electron Microscopy (SEM) and confocal Raman Imaging. Through RISE Microscopy ultra-structural surface properties can be linked to molecular compound information.
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iChrome MLE: More than just Four Lasers in a Box
Mar. 19, 2014

iChrome MLE: More than just Four Lasers in a Box

TOPTICA's iChrome MLE is more than just the sum of four lasers in one box: it fully integrates different lasers and enhances them with unique features! The system delivers highest output powers up to 100 mW - from a single-mode polarization-maintaining fiber. All laser parameters can be conveniently operated via one control interface. more
Leica DCM8: High-Definition Confocal Microscopy and Interferometry in One Instrument
Feb. 13, 2014

Leica DCM8: High-Definition Confocal Microscopy and Interferometry in One Instrument

Leica Microsystems has introduced the Leica DCM8 for non-destructive three-dimensional surface profiling. more
attocube´s Photonic Probe Station
Feb. 07, 2014

attocube´s Photonic Probe Station

Photonic Integrated Circuits (PIC) are hot candidates for being employed in the next generation of optical and quantum communication systems because of their promise regarding very high information transfer speed, robustness and the compatibility with standard microelectronics devices technology. Furthermore, the extremely high sensitivity of resonant nanophotonics structures to light-matter interactions makes them ideal for a new classes of sensors with a broad range of possible applications in physics, biology and chemistry. more
Advanced Training: Microscopy Courses at the EMBL in 2014
Jan. 24, 2014

Advanced Training: Microscopy Courses at the EMBL in 2014

The European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany offers a lot of different training courses in the field of microscopy.
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Superflat Beamsplitters
Dec. 30, 2013

Superflat Beamsplitters

Dichroics in highest level of performance are now available! They are manufactured by a special plasma coating technique, which results in a stress-free coating with fully dense dielectric films. Superflat dichroics with λ/10 specification after coating can be achieved on 2 mm substrates, no need of backside compensation or thick and expensive substrates. Typical applications are laser based spectroscopy methods like super-resolution microscopy, interferometry, TIRF microscopy, confocal microscopy etc. more
Why One Disk Is Better Than Two
Nov. 25, 2013

Why One Disk Is Better Than Two

A novel optical concept for a spinning disk confocal microscope is presented, which warrants maximal optical quality, speed and usability. It employs a single disk only instead of two, and it uses micromirrors instead of microlenses, thus minimizing chromatic aberrations and yielding an uncompromised performance over the full visible range from 405 - 700 nm. Careful optimization of coupling optics result in flat and homogenous illumination free of speckle artifacts, and the full optical performance is maintained over the full field of view. 
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Watching Tumor Cell Extravasation Using High-resolution Time-lapse Imaging
Sep. 24, 2013

Watching Tumor Cell Extravasation Using High-resolution Time-lapse Imaging

Cancer cells metastasize in several stages - first by invading surrounding tissue, then by infiltrating and spreading via the circulatory system. Some circulating cells work their way out of the vascular network, eventually forming a secondary tumor. While the initial process by which cancer cells enter the bloodstream - called intravasation - is well characterized, how cells escape blood vessels to permeate other tissues and organs is less clear. This process, called extravasation, is a crucial step in cancer metastasis. Now researchers at MIT have developed a microfluidic device that mimics the flow of cancer cells through a system of blood vessels. Using high-resolution time-lapse imaging, the researchers captured the moments as a cancer cell squeezes its way through a blood vessel wall into the surrounding extracellular matrix. The process is "highly dynamic," as they write in a paper published in Integrative Biology; a better understanding of it may help scientists identify therapies to prevent metastasis.
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