Nov. 25, 2013
A novel optical concept for a spinning disk confocal microscope is presented, which warrants maximal optical quality, speed and usability. It employs a single disk only instead of two, and it uses micromirrors instead of microlenses, thus minimizing chromatic aberrations and yielding an uncompromised performance over the full visible range from 405 - 700 nm. Careful optimization of coupling optics result in flat and homogenous illumination free of speckle artifacts, and the full optical performance is maintained over the full field of view.
moreSep. 24, 2013
Cancer cells metastasize in several stages - first by invading surrounding tissue, then by infiltrating and spreading via the circulatory system. Some circulating cells work their way out of the vascular network, eventually forming a secondary tumor. While the initial process by which cancer cells enter the bloodstream - called intravasation - is well characterized, how cells escape blood vessels to permeate other tissues and organs is less clear. This process, called extravasation, is a crucial step in cancer metastasis. Now researchers at MIT have developed a microfluidic device that mimics the flow of cancer cells through a system of blood vessels. Using high-resolution time-lapse imaging, the researchers captured the moments as a cancer cell squeezes its way through a blood vessel wall into the surrounding extracellular matrix. The process is "highly dynamic," as they write in a paper published in Integrative Biology; a better understanding of it may help scientists identify therapies to prevent metastasis.
moreAug. 20, 2013
Toptica's iChrome MLE is more than just the sum of four lasers in one box: it fully integrates different lasers and enhances them with unique features! The system delivers highest output powers up to 100 mW - from a single-mode polarization-maintaining fiber. All laser parameters can be conveniently operated via one control interface.
moreAug. 08, 2013
The International Symposium "Nanoscale Membrane Organisation" will take place in the hotel Vier Jahreszeiten, Schluchsse, Germany from October 24-25, 2013. Live cell imaging and confocal microscope techniques commonly used in the last 10 years have failed to resolve structures below the diffraction limit of 250 nm and therefore have missed many details of the nanoscale organization of membrane proteins. Recent technical developments and new concepts show that the plasma membrane is more highly organized at nanoscale distances than previously thought.
moreJun. 11, 2013
For excitable cells in which signaling events occur in milliseconds, a mathematical formalism for pixel-wise fitting generates virtually pixel noise-free image sequences from high-speed 2-dimensional confocal data. This approach provides novel insight into cardiac excitation-contraction coupling and its pathophysiology. Such an analytical approach can be extended into other biological systems to uncover otherwise inaccessible features of subcellular signal transduction in living cells.
moreDec. 18, 2012
Photonic Science Limited has introduced InGaAs cameras for the standard spectral range (900 to 1700nm) with extension in the visible range (400nm) as well as infrared region (2200nm).
moreDec. 11, 2012
The Cobolt Zouk is a continuous-wave (CW) single-frequency DPSS laser operating at 355 nm in a perfect quality TEM00 beam (M2<1.1) and with 10 or 20 mW output power.
A proprietary laser cavity design provides ultra-low noise performance of typically <0.2% rms (over 20 Hz-20MHz and over 10-40ºC), a narrow spectral linewidth of <1MHz and immunity to optical feedback.
moreDec. 08, 2012
The SymPhoTime 64 Software Package from PicoQuant is an integrated solution for fluorescence lifetime imaging and correlation microscopy that facilitates data acquisition as well as data analysis. A clearly structured layout and a wide range of customizable analysis procedures allow the user to focus on the results rather than on data processing. The SymPhoTime 64 is designed for a 64 bit operation system.
moreOct. 16, 2012
ibidi has announced the use of its µ-Slides, which have a special plastic bottom, for super-resolution imaging applications based on the microscopy method dSTORM.
moreOct. 09, 2012
Cobolt has recently introduced four new high power laser models on the 05-01 platform for high power single-frequency DPSS lasers.
The Cobolt Zouk 355 nm is now available with an output power up to 20mW, the Cobolt Samba 532 nm up to 1.5W, the Cobolt Flamenco 660 nm up to 0.5W and the Cobolt Rumba at 1064nm up to 3W.