Cryo Electron Tomography
Jan. 27, 2015
Neurodegenerative diseases like Alzheimer's or Parkinson's are caused by defect and aggregated proteins accumulating in brain nerve cells that are thereby paralyzed or even killed. In healthy cells this process is prevented by an enzyme complex known as the proteasome, which removes and recycles obsolete and defective proteins. Recently, researchers at the Max Planck Institute of Biochemistry in Martinsried were the first to observe proteasomes at work inside healthy brain cells. "When we saw the proteasomes on our screen, we were immediately aware of the importance of the results", remembers Shoh Asano, first author of the study. The results have now been published in the journal Science.
moreNov. 01, 2007
Cryo Electron Tomography: Unique Capability for Structural Biology InvestigationsCryo electron tomography's (CET) ability to visualize three dimensional biological structures - ranging in size from molecular to cellular - fills a critical gap between techniques with atomic resolution, such as x-ray diffraction (XRD) and nuclear magnetic resonance (NMR), and conventional light microscopy. However, it is CET's ability to investigate biological structures in their unperturbed, native context that makes it an indispensable tool in the currently exploding field of structural biology.