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Light Microscopy

Focus on Microscopy 2015
Nov. 19, 2014

Focus on Microscopy 2015

After the successful FOM2014 conference held in Sydney, Australia this year, it is a pleasure to announce FOM2015, the next Focus on Microscopy conference. It will take place in Göttingen, Germany in the week before Easter from Sunday March 29 to Wednesday April 1, 2015. Focus on Microscopy 2015 is the continuation of a yearly interdisciplinary conference series running now for well over two decades. It presents the latest innovations and new trends in multi-dimensional light microscopy, super-resolution and image processing together with their application in biology, medicine and material sciences.
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Third Harmonic Generation Microscopy
Nov. 11, 2014

Third Harmonic Generation Microscopy

Third Harmonic Generation (THG) microscopy is a non-fluorescent multi-photon technique that combines the advantages of label-free imaging with restriction of signal generation to the focal spot of the scanning laser. It allows three-dimensional imaging of refraction index mismatches and of hemoglobin. We applied it to image mouse tissues and to characterize blood vessels and blood flow velocity. In small arteries, THG line scanning reveals the pulse velocity curve and hence the heart rate.
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Light Sheet Illumination on a Chip
Oct. 27, 2014

Light Sheet Illumination on a Chip

Cell-derived membrane vesicles (MVs) that are released in body fluids, like blood or saliva, are potential biomarkers for diseases, such as cancer. Techniques capable of measuring MV properties, like size and concentration, directly in biofluids are thus needed. We developed a microfluidic chip with integrated light sheet illumination, and used it to perform fluorescence Single Particle Tracking (fSPT) size and concentration measurements of MVs in human tumor interstitial fluid.
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Nobel Prize 2014: Surpassing the Limitations of the Light Microscope
Oct. 08, 2014

Nobel Prize 2014: Surpassing the Limitations of the Light Microscope

For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation. Their ground-breaking work has brought optical microscopy into the nanodimension. more
Correlative Tabletop Fluorescence and Electron Microscope
Sep. 16, 2014

Correlative Tabletop Fluorescence and Electron Microscope

Delmic and Phenom World announce DelPhi, the world's first integrated tabletop fluorescence and electron microscope. Delmic produces high performance, user friendly, integrated solutions while Phenom World is a leading producer of electron microscopes. The DelPhi is a complete solution that makes it possible to do fast correlative microscopy with high overlay precision. The system is easy to use for both optical and electron microscopists and makes correlation intuitive and fully automated. more
Coupled Ge Quantum Dot Crystals
Jun. 16, 2014

Coupled Ge Quantum Dot Crystals

Coupled three-dimensional Ge quantum dot crystals (QDCs) are realized by multilayer growth of quantum dots (QDs) on patterned Si (001) substrates. With increasing the vertical periodic number of the QDCs, the photoluminescence (PL) spectral linewidth decreased exponentially, and so did the peak energy blueshift caused by increasing excitation power, which are attributed to the electronic coupling and thus the formation of miniband. more
New Book: Ex-vivo and In-vivo Optical Molecular Pathology
Jun. 05, 2014

New Book: Ex-vivo and In-vivo Optical Molecular Pathology

The result of a unique collaboration between clinicians, chemists and physicists, this book provides an unparalleled overview of a new generation of diagnostic tools in clinical pathology.
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High-Speed Microscopy
Apr. 22, 2014

High-Speed Microscopy

A high-speed scanning solution for transmitted-light microscopy which allows scanning of microtiter plates at unprecedented speed was developed at the Fraunhofer-Institute for Production Technology IPT in Aachen, Germany. The novel solution is based on a continuously moving scanning stage with synchronous z-position adjustment and flash illumination.
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How to Set Up a 3D-SIM Microscope (User Manual)
Apr. 01, 2014

How to Set Up a 3D-SIM Microscope (User Manual)

In the past two decades, light microscopy has seen a tremendous improvement with super-resolution techniques. Many of the super-resolution microscopes (3D-SIM, STED, and PALM/STORM) are now available in a commercial solution, and are entering labs and facilities worldwide. This offers an important step forward in the field of research in biology, but when not used in optimal conditions, those powerful techniques can give rise to artefacts. Here we focus on parameters that can deeply influence the image quality for 3D-SIM and the next challenges for this technique. more
14th International ELMI Meeting
Jan. 06, 2014

14th International ELMI Meeting

The 14th European Light Microscopy Initiative (ELMI2014) conference will be held in Oslo, Norway from May 20-23, 2014. ELMI is an internationally recognized meeting on Light Microscopy and offers a unique combination of lectures, exhibitions and hands-on workshops organized by leading microscopy companies. The meeting is aimed at a life sciences audience and specifically focuses on close collaborative interactions between companies, developers and researchers. Imaging methods from a wide range of research fields will be presented that are relevant to both new and expert users of electronic and photonic methods.
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