Oct. 08, 2014
For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation. Their ground-breaking work has brought optical microscopy into the nanodimension.
moreSep. 16, 2014
Delmic and Phenom World announce DelPhi, the world's first integrated tabletop fluorescence and electron microscope. Delmic produces high performance, user friendly, integrated solutions while Phenom World is a leading producer of electron microscopes. The DelPhi is a complete solution that makes it possible to do fast correlative microscopy with high overlay precision. The system is easy to use for both optical and electron microscopists and makes correlation intuitive and fully automated.
moreJun. 16, 2014
Coupled three-dimensional Ge quantum dot crystals (QDCs) are realized by multilayer growth of quantum dots (QDs) on patterned Si (001) substrates. With increasing the vertical periodic number of the QDCs, the photoluminescence (PL) spectral linewidth decreased exponentially, and so did the peak energy blueshift caused by increasing excitation power, which are attributed to the electronic coupling and thus the formation of miniband.
moreJun. 05, 2014
The result of a unique collaboration between clinicians, chemists and physicists, this book provides an unparalleled overview of a new generation of diagnostic tools in clinical pathology.
moreApr. 22, 2014
A high-speed scanning solution for transmitted-light microscopy which allows scanning of microtiter plates at unprecedented speed was developed at the Fraunhofer-Institute for Production Technology IPT in Aachen, Germany. The novel solution is based on a continuously moving scanning stage with synchronous z-position adjustment and flash illumination.
moreApr. 01, 2014
In the past two decades, light microscopy has seen a tremendous improvement with super-resolution techniques. Many of the super-resolution microscopes (3D-SIM, STED, and PALM/STORM) are now available in a commercial solution, and are entering labs and facilities worldwide. This offers an important step forward in the field of research in biology, but when not used in optimal conditions, those powerful techniques can give rise to artefacts. Here we focus on parameters that can deeply influence the image quality for 3D-SIM and the next challenges for this technique.
moreJan. 06, 2014
The 14th European Light Microscopy Initiative (ELMI2014) conference will be held in Oslo, Norway from May 20-23, 2014. ELMI is an internationally recognized meeting on Light Microscopy and offers a unique combination of lectures, exhibitions and hands-on workshops organized by leading microscopy companies. The meeting is aimed at a life sciences audience and specifically focuses on close collaborative interactions between companies, developers and researchers. Imaging methods from a wide range of research fields will be presented that are relevant to both new and expert users of electronic and photonic methods.
moreNov. 25, 2013
A novel optical concept for a spinning disk confocal microscope is presented, which warrants maximal optical quality, speed and usability. It employs a single disk only instead of two, and it uses micromirrors instead of microlenses, thus minimizing chromatic aberrations and yielding an uncompromised performance over the full visible range from 405 - 700 nm. Careful optimization of coupling optics result in flat and homogenous illumination free of speckle artifacts, and the full optical performance is maintained over the full field of view.
moreNov. 12, 2013
In contrast to fluorescence methods, bioluminescence microscopy does not need excitation by light. As photon emission results from a chemical reaction, results are highly specific and quantifiable. Until recently bioluminescence microscopy was difficult to approach as a result of rather dim signal intensities. Due to better probes and especially thanks to better and more specific instrumentation this technique has now become much more accessible and can in many situations outperform fluorescent approaches.
moreSep. 10, 2013
Scientists at the Campus Vienna Biocenter (Austria) have found a way to overcome some of the limitations of light microscopy. Applying the new technique, they can record the activity of a worm's brain with high temporal and spatial resolution, ultimately linking brain anatomy to brain function. The journal Nature Methods publishes the details in its current issue.