Nov. 28, 2013
Bioaxial, developers of super-resolution fluorescence microscopy for the extended imaging of live cells, announces the completion of a € 1.9 million equity investment by three new large investors; Amorcage Technologique Investissement, Inserm Transfert Initiative and Viveris Management plus a range of individual investors.
moreNov. 25, 2013
A novel optical concept for a spinning disk confocal microscope is presented, which warrants maximal optical quality, speed and usability. It employs a single disk only instead of two, and it uses micromirrors instead of microlenses, thus minimizing chromatic aberrations and yielding an uncompromised performance over the full visible range from 405 - 700 nm. Careful optimization of coupling optics result in flat and homogenous illumination free of speckle artifacts, and the full optical performance is maintained over the full field of view.
moreNov. 12, 2013
Optimized for Microscopy
This new Scientific CMOS camera is optimized for fluorescence microscopy and features faster frame rates and lower noise. optiMOS delivers 10 x the time resolution of CCD cameras without trading off on resolution or sensitivity.
moreNov. 12, 2013
In contrast to fluorescence methods, bioluminescence microscopy does not need excitation by light. As photon emission results from a chemical reaction, results are highly specific and quantifiable. Until recently bioluminescence microscopy was difficult to approach as a result of rather dim signal intensities. Due to better probes and especially thanks to better and more specific instrumentation this technique has now become much more accessible and can in many situations outperform fluorescent approaches.
moreOct. 29, 2013
After the successful FOM2013 conference held in Maastricht, the Netherlands this year, it is a pleasure to announce Focus On Microscopy 2014. It will take place in Sydney, Australia in the week before Easter from Sunday April 13 to Wednesday April 16, 2014.
moreSep. 20, 2013
Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease. Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics (FiO), The Optical Society's (OSA) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and fluids within tumors; examine abnormalities in the blood vessel network inside them; and observe how the tumors were affected by treatments.
moreAug. 08, 2013
The International Symposium "Nanoscale Membrane Organisation" will take place in the hotel Vier Jahreszeiten, Schluchsse, Germany from October 24-25, 2013. Live cell imaging and confocal microscope techniques commonly used in the last 10 years have failed to resolve structures below the diffraction limit of 250 nm and therefore have missed many details of the nanoscale organization of membrane proteins. Recent technical developments and new concepts show that the plasma membrane is more highly organized at nanoscale distances than previously thought.
moreAug. 07, 2013
Monitoring stem cells in their natural physiological environment is crucial to understanding stem cell differentiation and the generation of tissue. We applied high-resolution 3D multiphoton tomography in order to non-invasively visualize the stem cells of hair follicles. Single nestin GFP-expressing stem cells were tracked for up to five hours in living transgenic mice. The microenvironment was monitored by two-photon autofluorescence and second harmonic generation.
moreAug. 07, 2013
We combined holographic optical tweezers (HOT) with self-interference digital holographic microscopy (DHM). HOT allow flexible three-dimensional contactless moving of particles inside cells and positioning of bacteria on host cells while self-interference DHM provides simplified multi-focus quantitative phase imaging and 3D object tracking. Our results demonstrate novel ways for the analysis of the intracellular morphology and modeling of infection scenarios at single cell scale.
moreJul. 24, 2013
The newly developed STED-RICS microscopy method records rapid movements of molecules in live samples. By combining raster image correlation spectroscopy (RICS) with STED fluorescence microscopy, researchers of Karlsruhe Institute of Technology (KIT) opened up new applications in medical research, e.g. analyzing the dynamics of cell membranes at high protein concentrations. This method is now presented in Nature Communications.