Mar. 04, 2015
The highly innovative iXon Ultra 888 is the world's fastest Megapixel, Back-illuminated EMCCD camera, offering exceptional frame rates and single photon sensitivity across a large field of view. Building on a rich history of first to market innovation, the ‘supercharged' iXon Ultra 888, represents a massive performance boost for the largest available EMCCD sensor, as well as the first USB3 enabled EMCCD camera.
moreMar. 03, 2015
Live cell imaging is becoming an important tool in pharmaceutical research. Automated microscopy and image analysis are used to study, for example, the influence of compounds on cell cycle progression. Researchers want to find out which compounds arrest the cell cycle or how long they need to incubate at which concentration. Studying such effects requires complex image analysis workflows, which can be tedious to establish. Modular software helps to speed up this process.
moreFeb. 12, 2015
An international team led by Uppsala University and including scientists from DESY and the European XFEL has for the first time successfully imaged whole living bacterial cells with an X-ray laser. The method used in this experiment can produce results that are of higher spatial and temporal resolution than even the best optical microscopy techniques, with the added possibility of creating detailed 3D models of the cells. "When you really want to understand the details of a cell's functions, you need it alive", says Uppsala University Professor Janos Hajdu, one of the lead researchers in the experiment and an advisor to European XFEL. The technique, as described in the journal Nature Communications, allows scientists a clearer view into the complicated world of the cell.
moreJan. 27, 2015
Neurodegenerative diseases like Alzheimer's or Parkinson's are caused by defect and aggregated proteins accumulating in brain nerve cells that are thereby paralyzed or even killed. In healthy cells this process is prevented by an enzyme complex known as the proteasome, which removes and recycles obsolete and defective proteins. Recently, researchers at the Max Planck Institute of Biochemistry in Martinsried were the first to observe proteasomes at work inside healthy brain cells. "When we saw the proteasomes on our screen, we were immediately aware of the importance of the results", remembers Shoh Asano, first author of the study. The results have now been published in the journal Science.
moreJan. 21, 2015
Using a federal grant, some spare parts and a little ingenuity, University of Guelph (Canada) researchers have fashioned a spinning disk confocal microscope to study live cells for health, environmental and food applications. Researchers will use the new microscope for live 3D cell imaging.
moreJan. 19, 2015
Zeiss has introduced Zeiss LSM 800, a compact confocal laser scanning microscope for high-end confocal imaging. With highly sensitive GaAsP detector technology and fast linear scanning, the system provides high image quality and offers enhanced productivity and throughput, as well as greater flexibility in live cell imaging.
moreNov. 05, 2014
The Imaging and Cytometry Laboratory at the University of York  provides a facility committed to bringing state of the art technology to researchers with varying levels of expertise. A significant effort is devoted to training scientists in imaging and cytometry techniques to advance their projects. The facility is available to both internal and external users. Staff provides fully assisted technical support for the infrequent user while the facility is an excellent equipment resource for the experienced user.
moreOct. 07, 2014
Video to figure 1: The in vitro cell growth of a fibroblast L-929 culture was recorded every 10 minutes over 7 days in more than 1000pictures and visualized as a time-lapse video (fig. 1).
moreOct. 07, 2014
Video to Figure 5, right: With the large cell number inside the field-of-view it is also more likely to observe rare events in the cell culture, such as tripolar cell division of mutated cells. The unusual division was easy to identify in the hologram and was reconstructed for detailed examination (fig. 5 right). Analyzing the degenerated cell in the timelapse video, it became clear, that the dividing cells could not separate during the cytokinesis and merge in one cell body again.
moreOct. 07, 2014
Video to figure 5, middle: The segmented cells can be tracked over the whole experiment time to visualize cell migration, velocity, division rate and the cell lineage . These characteristics are used in chemotaxis assays, for example to analyze cell migration and division in wound healing assays . We visualized the tracks of several cells and noticed that, for instance mother cells, which cover a long distance between cell divisions hand down this attribute to their daughter cells.