Apr. 13, 2015
Soft X-ray microscopy in the water window has the advantage of a high spatial resolution as well as a good contrast and high penetration depth within biological samples. This makes it an ideal tool for the structural analysis of living cells without extensive sample preparation. The laboratory transmission X-ray microscope (LTXM) at the Berlin Laboratory for innovative X-ray Technologies (BLiX) has various fields of applications, one of which is the investigation of the penetration of nanoparticles in human skin.
moreMar. 19, 2015
Researchers at the Max Planck Florida Institute for Neuroscience and Kanazawa University (Japan) have succeeded in imaging structural dynamics of living neurons with an unprecedented spatial resolution. They have built a new Atomic Force Microscopy system optimized for live-cell imaging. The results have been published in the journal Scientific Reports.
moreMar. 04, 2015
The highly innovative iXon Ultra 888 is the world's fastest Megapixel, Back-illuminated EMCCD camera, offering exceptional frame rates and single photon sensitivity across a large field of view. Building on a rich history of first to market innovation, the ‘supercharged' iXon Ultra 888, represents a massive performance boost for the largest available EMCCD sensor, as well as the first USB3 enabled EMCCD camera.
moreMar. 03, 2015
Live cell imaging is becoming an important tool in pharmaceutical research. Automated microscopy and image analysis are used to study, for example, the influence of compounds on cell cycle progression. Researchers want to find out which compounds arrest the cell cycle or how long they need to incubate at which concentration. Studying such effects requires complex image analysis workflows, which can be tedious to establish. Modular software helps to speed up this process.
moreFeb. 12, 2015
An international team led by Uppsala University and including scientists from DESY and the European XFEL has for the first time successfully imaged whole living bacterial cells with an X-ray laser. The method used in this experiment can produce results that are of higher spatial and temporal resolution than even the best optical microscopy techniques, with the added possibility of creating detailed 3D models of the cells. "When you really want to understand the details of a cell's functions, you need it alive", says Uppsala University Professor Janos Hajdu, one of the lead researchers in the experiment and an advisor to European XFEL. The technique, as described in the journal Nature Communications, allows scientists a clearer view into the complicated world of the cell.
moreJan. 27, 2015
Neurodegenerative diseases like Alzheimer's or Parkinson's are caused by defect and aggregated proteins accumulating in brain nerve cells that are thereby paralyzed or even killed. In healthy cells this process is prevented by an enzyme complex known as the proteasome, which removes and recycles obsolete and defective proteins. Recently, researchers at the Max Planck Institute of Biochemistry in Martinsried were the first to observe proteasomes at work inside healthy brain cells. "When we saw the proteasomes on our screen, we were immediately aware of the importance of the results", remembers Shoh Asano, first author of the study. The results have now been published in the journal Science.
moreJan. 21, 2015
Using a federal grant, some spare parts and a little ingenuity, University of Guelph (Canada) researchers have fashioned a spinning disk confocal microscope to study live cells for health, environmental and food applications. Researchers will use the new microscope for live 3D cell imaging.
moreJan. 19, 2015
Zeiss has introduced Zeiss LSM 800, a compact confocal laser scanning microscope for high-end confocal imaging. With highly sensitive GaAsP detector technology and fast linear scanning, the system provides high image quality and offers enhanced productivity and throughput, as well as greater flexibility in live cell imaging.
moreNov. 05, 2014
The Imaging and Cytometry Laboratory at the University of York  provides a facility committed to bringing state of the art technology to researchers with varying levels of expertise. A significant effort is devoted to training scientists in imaging and cytometry techniques to advance their projects. The facility is available to both internal and external users. Staff provides fully assisted technical support for the infrequent user while the facility is an excellent equipment resource for the experienced user.
moreOct. 07, 2014
Video to figure 1: The in vitro cell growth of a fibroblast L-929 culture was recorded every 10 minutes over 7 days in more than 1000pictures and visualized as a time-lapse video (fig. 1).