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molecular biology
Monitoring Protein Molecules Using Gold Nanoparticles
Scientists at Johannes Gutenberg University Mainz (JGU) have developed a new method of observing individual proteins using gold nanoparticles. Detailed knowledge of the dynamics of proteins is necessary in order to understand the related biological processes that occur on the molecular level. To date, this information has been obtained by means of labeling proteins with fluorescent substances, but unfortunately this changes the proteins under investigation and thus influences the biological processes that are to be observed. more
Focused Ion Beam Microscopy: Deeper Insights into the Cell
Cryo-electron tomography provides high-resolution, three-dimensional insights into the cell. However, with this method only very small cells or thin peripheral regions of larger cells can be investigated directly. Scientists of the Max Planck Institute of Biochemistry (MPIB) in Martinsried, Germany have now developed a procedure to provide access to cellular regions which were previously nearly inaccessible.more
UltraPath XVI - Conference on Diagnostic Electron Microscopy, Basic Research & Oncology
The 16th Meeting of the Society for Ultrastructural Pathology (UltraPath XVI) will be held on August 6-10, 2012 in the historical town of Regensburg, Germany. The Society was formed in 1986 with the mission to support and promote the application of electron microscopy in pathological diagnosis and research of human diseases. Over the years the scope of biennial meetings expanded and includes immunochemistry, molecular and cellular biology. more
Polarization Extension for Confocal Laser Scanning Microscopes Allows Fluorescence Anisotropy ...
Since several years, time-resolved fluorescence measurements can be performed with commercially available confocal laser scanning microscopes (LSM) that have been upgraded with a suited upgrade kit. The polarization extension for PicoQuant's upgrade kit for LSM can now also perform polarization measurements. more
Combining Light-sheet Microscopy and Single Molecule Spectroscopy
Researchers can now watch molecules move in living cells, literally millisecond by millisecond, thanks to a new microscope developed by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Published online in Nature Biotechnology, the new technique provides insights into processes that were so far invisible.moreAug. 26, 2010
Visualizing Viruses
In the war against infectious disease, identifying the culprit is half the battle. Now, research professor Shaopeng Wang and his colleagues at Arizona State University's Biodesign Institute, USA describe a new method for visualizing individual virus particles. Their research opens the door to a more detailed understanding of these minute pathogens, and may further the study of a broad range of micro- and nanoscale phenomena. The group's findings appear in the August 23rd Proceedings of the National Academy of Science, advanced online issue. more
Macromolecular Complexes
CryoEM can be divided into three different sub-disciplines: electron crystallography where the macromolecules are arranged periodically into thin crystals, single particle cryoEM of randomly oriented isolated macromolecular assemblies and electron tomography of vitreous specimens containing objects in situ or in isolated form but being reconstructed individually. These methods provide a comprehensive, complementary approach of transmission electron microscopy (TEM) for studies of biological structure reaching from the atomic to the cellular level.more
Some Like It Hot
The combination of advanced molecular biology and multi-dimensional microscopy can generate fascinating new insights into key biological functions and processes. Here we report on the development of a new method and device to investigate temperature sensitive mutations and/or temperature dependent biological processes at unprecedented high temporal-spatial resolution. Studying Gene Functions more
6th International ELMI Meeting
6th International ELMI Meeting. more- Legal
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