Nov. 01, 2007
Cryo Electron Tomography: Unique Capability for Structural Biology InvestigationsCryo electron tomography's (CET) ability to visualize three dimensional biological structures - ranging in size from molecular to cellular - fills a critical gap between techniques with atomic resolution, such as x-ray diffraction (XRD) and nuclear magnetic resonance (NMR), and conventional light microscopy. However, it is CET's ability to investigate biological structures in their unperturbed, native context that makes it an indispensable tool in the currently exploding field of structural biology.
moreMay. 31, 2005
Biological Applications of Scanning Probe Microscopy. Scanning probe microscopes (SPMs) have now become established as the foremost tools in the imaging of surfaces and surface–confined structures at up to angstrom resolution. Whilst spectroscopic methods such as Raman, ellipsometry and surface plasmon resonance continue to provide useful information on interfaces, they remain tools of restricted spatial resolution and are accordingly limited to measurements of bulk averages.