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structural biology

Mapping Bacterial Membrane Proteins with Super-Resolution Microscopy
Sep. 03, 2013

Mapping Bacterial Membrane Proteins with Super-Resolution Microscopy

Using super-resolution microscopy researchers have found another chink in bacteria's armour, mapping for the first time the structure of a protein that plays an important role helping infection gain a foothold in the body. Published in Nature a group of international scientists from Monash University, the National Institutes of Health (NIH), the Georgia Institutes of Technology and the Diamond Light Source have determined the structure, in two species of bacteria, of an essential membrane protein called BamA.
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In Situ Molecular Microscopy
Jul. 31, 2013

In Situ Molecular Microscopy

We present a novel approach for visualizing viral assemblies in liquid using transmission electron microscopy (TEM). We utilize a microfluidic chamber that fits within a TEM specimen holder and while inserted in the column, is completely isolated from the vacuum. This configuration proves suitable for imaging and reconstructing viral complexes in solution at 2.5-nanometer resolution. more
X-Ray Source for Structural Biology and Material Science
Nov. 13, 2012

X-Ray Source for Structural Biology and Material Science

Rigaku Corporation has introduced the FR-X rotating anode X-ray source. more
Free-electron Lasers Reveal Detailed Architecture of Proteins
Jun. 04, 2012

Free-electron Lasers Reveal Detailed Architecture of Proteins

In the centennial year of Max von Laue's discovery that X-ray diffraction can be used to unravel the atomic architecture of molecules, a new approach to the determination of high-resolution structures has been demonstrated. An international team of researchers has analyzed tiny protein crystals using short pulses of X-ray light from the hard X-ray free-electron laser, the US Department of Energy's 300 million dollar Linac Coherent Light Source at Stanford. more
To Enable New Structural Biology Research
Jan. 05, 2010

To Enable New Structural Biology Research

The University of Texas El Paso (UTEP), USA, has selected a JEOL cryo-electron microscope for its emerging structural biology program to be housed in a new building planned for completion in 2011 on the UTEP campus. The JEM-3200FS that was ordered from JEOL USA is a 300 keV cryo-TEM with an omega energy filter for increased contrast and high resolution. The UTEP research program directed by structural biologists Dr. Ricardo Bernal and Dr. Chuan "River" Xiao, will utilize cryo-electron microscopy for single particle reconstructions and tomography. more
Cryo Electron Tomography: Unique Capability for Structural Biology Investigations
Nov. 01, 2007

Cryo Electron Tomography: Unique Capability for Structural Biology Investigations

Cryo Electron Tomography: Unique Capability for Structural Biology InvestigationsCryo electron tomography's (CET) ability to visualize three dimensional biological structures - ranging in size from molecular to cellular - fills a critical gap between techniques with atomic resolution, such as x-ray diffraction (XRD) and nuclear magnetic resonance (NMR), and conventional light microscopy. However, it is CET's ability to investigate biological structures in their unperturbed, native context that makes it an indispensable tool in the currently exploding field of structural biology. more
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