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Super-Resolution Microscopy

Super-Resolution Microscopy; Revealing the Link Between Genome Packaging and Cell Pluripotency
Mar. 23, 2015

Super-Resolution Microscopy; Revealing the Link Between Genome Packaging and Cell Pluripotency

A study using Super-resolution microscopy reveals that our genome is not regularly packaged and links these packaging differences to stem cell state. The multidisciplinary approach allowed scientists to view and even count, for the first time, the smallest units for packaging our genome. A joint patent has been filed by ICFO and CRG, who are now exploring business opportunities for marketing the classification and determination of the degree of pluripotency of stem cells before their use in cell therapy or research in biomedicine. The work, published in Cell, is a successful example of the importance on having multidisciplinary projects and collaborations. This study has brought together biologists and physicists from the Centre for Genomic Regulation (CRG) and the Institute of Photonic Sciences (ICFO), both in Barcelona, Spain.
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Super-Resolution Microscopy: Unraveling the Mechanistic Details of IL-37’s Powerful Effects
Mar. 12, 2015

Super-Resolution Microscopy: Unraveling the Mechanistic Details of IL-37’s Powerful Effects

Scientists who have discovered the mechanism of a protein that suppresses inflammation in the body, say the information could potentially be used to develop new drugs to control inflammation. To unravel the mechanistic details of IL-37's powerful effects, the research team used the Nobel Prize winning technique, Super-Resolution Microscopy at Monash Micro Imaging and the Monash Institute of Pharmaceutical Sciences. The new study, published in Nature Immunology, deciphers the mechanisms of how the body uses IL-37 as a molecular signal to regulate and control inflammation.
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Mar. 06, 2015

Stefan Hell and Eric Betzig at the World of Photonics Congress in Munich

Nobel Prize winners will be speaking at the World of Photonics Congress 2015: the lectures delivered by professors Stefan Hell and Eric Betzig deal with Super-Resolved Fluorescence Microscopy. The innovative microscopic procedure provides researchers with unprecedented insights into the nano building blocks of life.
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iXon Ultra 888: World’s Fastest Megapixel Back-illuminated EMCCD
Mar. 04, 2015

iXon Ultra 888: World’s Fastest Megapixel Back-illuminated EMCCD

The highly innovative iXon Ultra 888 is the world's fastest Megapixel, Back-illuminated EMCCD camera, offering exceptional frame rates and single photon sensitivity across a large field of view. Building on a rich history of first to market innovation, the ‘supercharged' iXon Ultra 888, represents a massive performance boost for the largest available EMCCD sensor, as well as the first USB3 enabled EMCCD camera. more
Super-Resolution Microscopy: Developing New DNA-based Fluorescence Probes
Jan. 17, 2015

Super-Resolution Microscopy: Developing New DNA-based Fluorescence Probes

A new Emmy Noether Junior Research Group based in LMU's Faculty of Physics has just begun its quest for new methodologies in super-resolution microscopy specifically tailored for biomedical applications.
The goal of the newly established Emmy Noether Research Group in the Faculty of Physics at LMU is to enhance the technical capabilities of fluorescence microscopy specifically in the context of its biomedical application. The research team is headed by Dr. Ralf Jungmann, who holds a dual appointment as a Research Group Leader at the Max Planck Institute of Biochemistry in Martinsried. Jungmann and his team hope to develop new DNA-based fluorescence probes that enable them to simultaneously visualize diverse cell components at the single-molecule level.
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Dec. 27, 2014

Microscopy Market - Global Forecast to 2019

The report segments the global microscopy market by product, application, end user, and geography. The optical microscopy segment accounted for the largest share of the global microscopy market, by product. However, the electron microscopes segment is expected to grow at the highest CAGR in the forecast period. Super-resolution microscopes are the key playing field in the microscopy product market, owing to ongoing technological advancements in this segment.
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Sub-25 nm Resolution STED Microscopy
Dec. 01, 2014

Sub-25 nm Resolution STED Microscopy

STED microscopy was the first method to fundamentally break the diffraction barrier. Twenty year later, the latest generation of commercial STED microscopes further boosts the resolution by using programmable SLMs to shape and optimize the STED light pattern. This enables the highest resolutions currently possible with figures below 25 nm in 2D and below 80 x 80 x 90 nm in 3D.
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Focus on Microscopy 2015
Nov. 19, 2014

Focus on Microscopy 2015

After the successful FOM2014 conference held in Sydney, Australia this year, it is a pleasure to announce FOM2015, the next Focus on Microscopy conference. It will take place in Göttingen, Germany in the week before Easter from Sunday March 29 to Wednesday April 1, 2015. Focus on Microscopy 2015 is the continuation of a yearly interdisciplinary conference series running now for well over two decades. It presents the latest innovations and new trends in multi-dimensional light microscopy, super-resolution and image processing together with their application in biology, medicine and material sciences.
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Super-Resolution Microscopy: Searching for Weapons in the Fight against Drug-Resistant Bacteria
Nov. 07, 2014

Super-Resolution Microscopy: Searching for Weapons in the Fight against Drug-Resistant Bacteria

With the help of super-resolution microscopy, new research at University of Toronto Mississauga could help stop "superbugs" in their tracks. The Milstein Lab is taking a very close look at bacterial cells in hopes of figuring out how to stop the spread of antibiotic-resistant bacteria known as CRE or carbapenem-resistant Enterobacteriaceae. Dubbed the "nightmare bacteria," CRE infections are immune to even the strongest antibiotics and have the ability to transfer that drug resistance to other bacteria.
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New Fluorescence Probes for Live-Cell Imaging
Oct. 30, 2014

New Fluorescence Probes for Live-Cell Imaging

We review here a new generation of far-red fluorescent probes for live-cell imaging, which are based on a novel cell-permeable silicon rhodamine (SiR) dye. These probes combine a variety of desirable features, such as excellent selectivity, fluorogenicity, high brightness and low cytotoxicity, rendering them ideal probes for conventional and state-of-the-art super-resolution microscopy. Application of these new probes in combination with STED microscopy revealed for the first time the nine-fold symmetry of the centrosome and confirmed the spatial organization of actin in the axon of cultured neurons in living cells.
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