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Super-Resolution Microscopy

Labeling & Nanoscopy Conference
Aug. 11, 2014

Labeling & Nanoscopy Conference

The conference Labeling & Nanoscopy will take place from 24-26 September 2014 in Heidelberg, Germany. This conference brings together experts in fluorescence and labeling with those designing and applying new concepts of far-field optical nanoscopy.
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Super-Resolution Microscopy
Aug. 07, 2014

Super-Resolution Microscopy

In the year 2008 Nature Methods has selected super-resolution microscopy or nanoscopy as "method of the year" [1]. Since that time super-resolution microscopy has emerged from specialized physics laboratories and become a powerful tool for biologists. The field of application is constantly growing and since recently even expanding in the axial dimension for single molecule localization microscopy. The process to get high quality super-resolution images can be divided in three important steps: sample preparation, image acquisition and image processing. Especially the first step has to be considered with a lot of care, since higher resolving power demands more stringent sample preparation.
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Carl Zeiss´s LSM 880 with Airyscan: Confocal Laser Scanning Microscope for Super-resolution Microscopy
Jul. 31, 2014

Carl Zeiss´s LSM 880 with Airyscan: Confocal Laser Scanning Microscope for Super-resolution ...

Carl Zeiss Microscopy has released LSM 880 with Airyscan. The confocal laser scanning microscope enables fast and high sensitivity super-resolution microscopy in x, y and z, and high image-acquisition speed in one system.
With the new confocal technology, users achieve a 1.7x higher resolution in all spatial dimensions, 140 nm laterally and 400 nm axially. The improved sensitivity leads to better image quality and increased speed. The whole imaging process is possible with standard sample preparation and labeling protocols. more
Jul. 31, 2014

Bruker Announces Acquisition of High-Speed, 3D Super-Resolution Fluorescence Microscopy Company ...

Bruker announced that it has acquired Vutara, a provider of high-speed, three-dimensional (3D), super-resolution fluorescence microscopy for life science applications. Transaction details were not disclosed. Vutara's estimated revenue for the full year 2014 is expected to be approximately $-US 2 million.
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Multicolor Super-Resolution Fluorescence Imaging
Jul. 07, 2014

Multicolor Super-Resolution Fluorescence Imaging

Stochastic optical reconstruction microscopy (STORM) has the potential to increase the resolution in fluorescence light microscopy up to tenfold. This helps scientists to get new insights into biological processes and structural details. For STORM fluorophores are utilized that show a blinking behavior [1] switching between a fluorescent and a nonfluorescent state. This was initially described for pairs of cyanine dyes, one activator dye and one reporter dye [1] in close proximity to each other. For multicolor STORM the channels are separated by using different activator dyes while the reporter dye is the same in each channel [2].
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Lensless Imaging without Spectral Bandwidth Limitations or Sample Requirements
Jun. 26, 2014

Lensless Imaging without Spectral Bandwidth Limitations or Sample Requirements

The overwhelming majority of past and present imaging systems use a lens to focus the subject of interest, even today's super-resolution light microscopes that breach the diffraction limit through ingenious experimental methods. Lensless imaging offers the prospect of a radical improvement in resolution by reconstructing a high-resolution image of an object from one or more diffraction patterns.
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ELMI 2014
Jun. 24, 2014

ELMI 2014

The 14th European Light Microscopy Initiative (ELMI) meeting, which brings together leading scientists from both academia and industry, was held in May at Holmenkollen in Oslo. This year's meeting, playfully described in the closing speeches by one of the Steering Committee as "Exquisite Lifestyle Meets Imaging", was certainly an enjoyable occasion. As many of the participants have been attending regularly since the inception of the ELMI, the start of the conference resembled a family reunion, with greetings and updates between old friends and colleagues. This intimate and relaxed atmosphere continued throughout the 4-day schedule.
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Kavli Prize in Nanoscience 2014 for Super-Resolution Microscopy
Jun. 03, 2014

Kavli Prize in Nanoscience 2014 for Super-Resolution Microscopy

The Kavli Prize in Nanoscience is shared between Thomas W. Ebbesen, Université Louis Pasteur, Université de Strasbourg, France, Stefan W. Hell, Max Planck Institute for Biophysical Chemistry, Germany, and Sir John B. Pendry, Imperial College London, UK. They receive the prize "for transformative contributions to the field of nano-optics that have broken long-held beliefs about the limitations of the resolution limits of optical microscopy and imaging".
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Neuroscience: First 3D Model of a Synapse
Jun. 02, 2014

Neuroscience: First 3D Model of a Synapse

Synapses are the contacts between nerve cells that allow the flow of information that makes our brains work. However, the molecular architecture of these highly complex structures has been unknown until now. A research team from Göttingen, led by Prof. Silvio O. Rizzoli from the DFG Research Center and Cluster of Excel-lence Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) of the University Medical Center Göttingen, managed to determine the copy numbers and positions of all important building blocks of a synapse for the first time.
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Live-Cell Microscopy: A New Molecule for High-Resolution Imaging of the Cytoskeleton
May. 27, 2014

Live-Cell Microscopy: A New Molecule for High-Resolution Imaging of the Cytoskeleton

Like our own bodies, cells have their own skeletons called ‘cytoskeletons' and are made of proteins instead of bones. These network-like structures maintain the cell's shape, provide mechanical support, and are involved in critical processes of the cell's lifecycle. The cytoskeleton is an object of intense scientific and medical research, which often requires being able to observe it directly in cells. Ideally, this would involve highly-fluorescent molecules that can bind cytoskeletal proteins with high specificity without being toxic to the cell. Publishing in Nature Methods, EPFL scientists have exploited the properties of a new fluorescent molecule, also developed at EPFL, to generate two powerful probes for the imaging of the cytoskeleton with unprecedented resolution. These probes pave the way for the easier and higher quality imaging of cells, offering many scientific and medical advantages.
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