Nov. 16, 2010

Confocal Nanoscopy Goes Multicolor

Scientists long to understand the architecture of life. They want to learn how biological structures are arranged in respect to one another. Do they co-localize within or are they excluded from the same superstructure? Does localization follow a special pattern and how does the overall arrangement reflect the biological function? Multicolor superresolution imaging allows these fundamental questions to be addressed by far-field fluorescence microscopy in unprecedented detail. moreMay. 17, 2010

Superresolution

With Elyra, Carl Zeiss is introducing a product family that allows the superresolution PAL-M and SR-SIM microscopy techniques to be comprehensively used and individually combined. This enables scientists in biomedical research to image cellular structures marked with fluorescent dyes with maximum spatial resolution below the classic diffraction limit of microscopes, i.e. under 200 nanometers. This offers new possibilities for the analysis of the spatial relationship between the smallest cellular components down to the individual molecule. moreFeb. 08, 2010

The Fast Track to Superresolution

The Leica TCS STED CW is the most uncomplex way to nanoscopy for research. The system resolves structures smaller than 80 nm - with purely optical methods. The depletion lasers and emission lasers in the visible spectral range enable researchers to use conventional dyes such as Alexa 488, FITC and Oregon Green and beyond that established fluorescence proteins such as YFP. Dynamics of sub-cellular processes can be imaged due to this flexibility and the system's ability of fast data acquisition. This means: live cell imaging below the diffraction limit. more