Dec. 30, 2009

The Dynamic of Synthetic Proteo-nucleic Complexes

Synthetic proteo-nucleic structures (PDNA) encompassing a ss-DNA sequence covalently attached to a cytochrome b5-derived protein domain through a synthetic linker were designed. PDNAs can bind to natural or supported membranes through an histidine-tag-nickel-NTA modified phospholipids. Alternatively the structures can be attached, while keeping free lateral diffusion capabilities, by interaction of the protein his-tag with a substrate supported field of nickel ions. more