Oct. 08, 2013
Through a combination of transmission electron microscopy (TEM) and their own unique graphene liquid cell, researchers at the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have recorded the three-dimensional motion of DNA connected to gold nanocrystals (see movie). This is the first time TEM has been used for 3D dynamic imaging of so-called soft materials. The results were published in the journal Nano Letters.
moreSep. 23, 2013
Mineralized human dental tissues were studied by advanced analytical transmission electron microscopy (TEM) techniques. The Ca/P and Mg/P at % ratios were determined employing energy dispersive X-ray spectroscopy (EDX) measurements. Significantly lower Ca/P and higher Mg/P at % ratios were measured in peritubular dentine compared to intertubular dentine, suggesting the incorporation of Mg in the hydroxylapatite lattice by substituting Ca. Improvement of TEM sample preparation is demonstrated.
moreJul. 31, 2013
We present a novel approach for visualizing viral assemblies in liquid using transmission electron microscopy (TEM). We utilize a microfluidic chamber that fits within a TEM specimen holder and while inserted in the column, is completely isolated from the vacuum. This configuration proves suitable for imaging and reconstructing viral complexes in solution at 2.5-nanometer resolution.
moreJul. 01, 2013
The 11 Megapixel Morada G2 TEM camera from Olympus Soft Imaging Solutions offers an extremely large field of view combined with maximum resolution, high frame rates moreJun. 18, 2013
Correlative light and electron microscopy (CLEM) combines the versatility of fluorescence microscopy (FLM) with the spatial resolution of transmission electron microscopy (TEM). For the analysis of tissues single resin or cryo-sections are incubated with fluorochrome- and gold-labeled probes. Areas of interest are selected at the FLM, and analyzed in the TEM at high resolution. This way, fluorescence is directly correlated to subcellular structures and/or corresponding immunogold signals.
moreMay. 06, 2013
Ted Pella, Inc has announced the availability of the new research-ready Pelco graphene TEM support films.
The films are supported by lacey carbon film on a 300 mesh copper grid. The single, continuous graphene sheet covers the entire 300 mesh area of the TEM grid. This creates a usable area of around 75% of the TEM grid, leaving plenty of space for specimens or experiments. The Pelco graphene TEM support films with the large area continuous film can be used directly out of the box.
moreApr. 29, 2013
The macroscopic effects of certain nanoparticles on human health have long been clear to the naked eye. What scientists have lacked is the ability to see the detailed movements of individual particles that give rise to those effects. In a recently published study, scientists at the Virginia Tech Carilion Research Institute invented a technique for imaging nanoparticle dynamics with atomic resolution as these dynamics occur in a liquid environment. The results will allow, for the first time, the imaging of nanoscale processes, such as the engulfment of nanoparticles into cells.
moreMar. 14, 2013
Single Electron Events (SEE) have been used to quantify the point spread function of several cameras for Transmission Electron Microscopy (TEM). The spatial resolution is measured by the Single Electron Modulation Transfer Function (MTFSEE) compared with the MTF generated by standard knife edge experiment. In addition, the sensitivity of the camera as a function of high tension has been measured, showing an excellent Signal-to-Noise Ratio (SNR) from 300 kV down to 8 kV.
moreDec. 12, 2012
The group of Dr Rikke Meyer from the interdisciplinary Nanoscience Center (iNANO) at Aarhus University, Denmark has used AFM and single-cell force spectroscopy to work at the interface between microbiology and nanoscience in the quest to understand how bacteria form biofilms and how this may be prevented.
moreOct. 18, 2012
The EasyLift nanomanipulator from FEI allows improved ease of use, reliability, precision and integration in preparing ultra-thin samples for analysis in a transmission electron microscope (TEM).
It is designed specifically for in-situ liftout TEM sample preparation and other demanding nanomanipulation activities. EasyLift is now available on the Helios NanoLab and Versa 3D DualBeam systems.