Mar. 03, 2016

Non-Invasive Tomography of Living Cells

Non-Invasive Holo-Tomographic System for Live Cell Nanoscopy

Since the discovery of the cell as the basis of all life on earth, scientists became aware that unveiling the microcosm inside cells would open a objective amount of possibilities. However, cell’s small dimensions and transparent nature made this mission very challenging. The most used approach to address these issues is to combine conventional microscopy with chemical markers to increase contrast. Most of these techniques are invasive to the cells with risk of damaging and results falsification. This article presents a novel non-invasive imaging approach for quantitative analysis and differentiation of cell components in 3D [1].

Read the complete article as PDF (Read Whitepaper)

[1] Y. Cotte et al.: Marker-free Phase Nanoscopy, Nature Photonics, vol. 7, pp.113-117 (2013)
[2] Y. Cotte et al.: Microscopy image resolution improvement by deconvolution of complex fields, Opt. Express, vol 18, n°1, p. 19462-19478 (2010)
[3] L. Pollaro et al.: Digital Staining: Microscopy of Live Cells without Invasive Chemicals, Microscopy Today, vol 23, n°4, pp. 12-17 (2015)
[4] E. Wolf: Principles and development of diffraction tomography, Trends in Optics, vol. 3, pp.

83–110 (Academic, 1996)

Lisa Pollaro1
Sebastien Equis1
Bastien Della Piazza1
Yann Cotte1

1Nanolive SA, Ecublens, Switzerland



Lisa Pollaro, PhD, Communication manager
Nanolive SA
Ecublens, Switzerland

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