Cryo-EM Allows the Study of Biomolecules at Atomic Resolution Prepared under Cryogenic Conditions
Statement of Markus Lusser, President of Leica Microsystems for this year Nobel Prize in Chemistry: “We are pleased that this honor conferred by the Nobel Prize Committee once again highlights the enormous importance of microscopy for its contributions to scientific breakthroughs. This work on cryo-EM imaging and the associated sample preparation methods has created the basis for making a leap ahead in structural biology. Highly resolved, three-dimensional images of protein structures help researchers investigate biological processes down to the sub-molecular level of detail which is imperative for understanding the chemistry of life and designing novel therapies."
One month ago, the Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2017 to Jacques Dubochet, Joachim Frank, and Richard Henderson, for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution. Leica Microsystems sincerely congratulates the scientists for this recognition of their great scientific achievements which have moved biochemistry into a new era.
Leica Microsystems has been offering a wide range of highly sophisticated products for cryo-EM sample preparation and actively engaged in delivering solutions for the cryo-EM community for over 10 years. Leica remains committed to developing improved solutions to support diverse cryo-applications, such as, grid plunging, high pressure freezing, shuttle sample transfer, cryo-ultramicrotomy, and a cryo-CLEM system for identification of single particles
Cryo-EM is increasingly becoming a mainstream technology for studying the architecture of cells, viruses, lipid nanocarriers, nanoemulsions, and protein assemblies at molecular resolution. The cellular structure and composition are maintained under physiological conditions by rapid cooling to liquid nitrogen temperature.
This is the reason why molecular movements are stabilized, the structure is preserved and observed in a cryo-EM in its natural state.
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