Imaging & Microscopy en NEUBIAS 2018 Bioimage analysts from all over Europe and beyond met this year in the beautiful city of Szeged, Hungary for the second annual Network of European Bioimage Analysts (NEUBIAS) conference, which consisted of a symposium preceded by two training schools. Symposium Tue, 19 Jun 2018 05:09:00 +0000 International Symposium on Confocal Raman Imaging The 15th Confocal Raman Imaging Symposium will be held on September 24 - 26, 2018 in Ulm (Germany). Speakers from universities and industry will talk about aspects of cutting edge research using Raman imaging. Researchers from around the world are invited to Mon, 18 Jun 2018 13:30:00 +0000 Switching to a New Perspective Confocal Raman imaging is a well-established technique for investigating the chemical and molecular compositions of solid and liquid samples. Its varied fields of application in academia and industry range from materials and surface sciences to environmental and geo sciences to life sciences and pharmaceutics. Mon, 18 Jun 2018 13:00:00 +0000 AFM-Based Nanomechanics Atomic Force Microscopes (AFM), once typically found in the basements of physics’ schools, are now beginning to populate life sciences research centers. Undeniably, the rise of mechanobiology research has found an ideal partner in AFM, to achieve not only high-resolution imaging of living samples, but also mechanical characterization of cells and tissues. Now that the study of cellular mechanical state is gaining relevance also in biomedical research, AFM is poised to make further contributions in the study of (patho)physiology and disease. Mon, 18 Jun 2018 06:00:00 +0000 Improving Fluorescence Microscopy with New Technique A novel technique developed by researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) will help shine new light on biological questions by improving the quality and quantity of information that can be extracted in fluorescence microscopy. Fri, 15 Jun 2018 06:54:00 +0000 Programmable LEDs Benefit Cell Viability In live-cell fluorescence microscopy, maintaining a specimen’s viability is essential to experimental efficiency and reliability. Thu, 14 Jun 2018 07:31:00 +0000 Seeing Inside Liquids in 3D Water is present everywhere in our everyday life. This paper shows that it is possible to perform 3D observations directly on liquids, with a resolution of a few tens of nanometer. This opens the route to following the materials architecture in 3D during its synthesis or shaping process. The results obtained on water containing latex particles and surfactant molecules, a material used in the construction industry for thermal insulation applications are presented. Introduction Mon, 11 Jun 2018 05:29:00 +0000 Laser Technology: New Approach to Generating Ultrashort Pulses A laser synthesizer developed by an A*STAR researcher and his overseas collaborators produces infrared pulses shorter than the wave period, which could enable scientists to probe how electrons move inside atoms and solids. Importantly, these pulses are readily absorbed by many atoms and molecules because their wavelengths lie in the mid-infrared range. Thu, 07 Jun 2018 09:24:00 +0000 Spherical Particles Ensure Better Resolution of Materials not Transmitting Light Scientists of Tomsk Polytechnic University jointly with colleagues from Bangor University (United Kingdom) proposed a method to improve the resolution of optical microscopes operating in the reflection mode, i.e. visualizing materials not transmitting light.  Spherical dielectric particles with a refractive index close to air were applied as a superlens for the microscope.  The objective of the research team is to improve the resolution of optical microscopes in this mode thus making them as close as possible to the sharpest nanoscopes. Thu, 07 Jun 2018 08:11:00 +0000 Primed Conversion The introduction of the green fluorescent protein (GFP) as optical marker in 1994 enabled a plethora of applications in biological and biomedical research, yielding revolutionary insight into various cell and protein dynamics [1]. Ever since, many proteins that cover the entire visible spectrum have been engineered and successfully used. Wed, 06 Jun 2018 06:37:00 +0000 Silent and Powerful Light Source for Fluorescence Microscopy AHF analysentechnik has extended its portfolio of light sources with the new "niji" multichannel 7 LED light source from Bluebox Optics. Mon, 04 Jun 2018 16:56:00 +0000 2018 WITec Paper Award Every year WITec, the Raman imaging company, recognizes three peer-reviewed publications that stand out in terms of originality and significance and feature data acquired with a WITec microscope. This year, scientists from universities and institutes in Bochum, Bayreuth and Minneapolis received the awards. Some 80 publications were submitted, all documenting the versatility of confocal Raman imaging for the investigation of materials. The Gold Paper Award Fri, 01 Jun 2018 09:55:00 +0000 Using Silicon Nanoparticles for Bioimaging and Drug Delivery An international research team has studied a new cell visualization and drug delivery system based on nanoparticles coated with luminescent dye molecules. Scientists have found out that the particle material and the distance between the dye and the particle’s surface affect the intensity of the luminescent signal. It turned out that silicon nanoparticles coated with dye molecules are more efficient than similar particles made of gold. Thanks to their biocompatibility, silicon particles can be used for cell visualisation and drug delivery. Wed, 30 May 2018 11:10:00 +0000 Correlative Microscopy: Combining STED with Scanning Ion Conductance Microscopy for Better Cell Monitoring In a first proof-of-concept study, researchers at Ruhr-Universität Bochum (RUB) have combined two microscopy methods that render both a cell’s surface and the distribution of a protein in the cell visible, at a resolution in the nanometre range. The method can be used for living cells. It might for example help analyse how cancer metastases are formed or assess the efficacy of specific drugs. Tue, 29 May 2018 07:54:00 +0000 Finally… a true arc lamp replacement. Make the switch to LED X-Cite XYLIS is a true arc lamp replacement for routine and advanced fluorescence imaging. With coverage from DAPI to Cy7, X-Cite XYLIS has the broadest spectrum available in a white light LED and rivals arc lamps for brightness – making it ideal for both compound and stereomicroscopes. Tue, 29 May 2018 05:12:00 +0000 New Wavelengths for Raman by Cobolt Cobolt AB, a part of Hübner Photonics, introduces new wavelengths on the 08-01 Series of 457 nm, 473 nm, 515 nm, 660 nm and 1064 nm, complementing already available wavelengths of 405 nm, 532 nm, 561 nm and 785 nm. The 08-01 series of single frequency and narrow linewidth lasers are ideal for Raman spectroscopy applications. Mon, 28 May 2018 07:05:00 +0000 Atomic Force Microscopy: Bulit your own AFM Using a new mode of atomic force microscopy, researchers at EPFL have found a way to see and measure protein assembly in real time and with unprecedented detail (more). Interested in this instrument? Come and make your own! Sun, 27 May 2018 12:52:00 +0000 Atomic Force Microscopy: Observing Cellular Activity, One Molecule at a Time Using a new mode of atomic force microscopy, researchers at EPFL have found a way to see and measure protein assembly in real time and with unprecedented detail. Fri, 25 May 2018 15:14:00 +0000 Olympus: Participate in the Image of the Year 2018 Show us and the world the art of light microscopy and illustrate the details of life with your most beautiful image. Participate now in the Olympus Image of the Year 2018 Award for life science microscopy. Prizes are: • CX23 Microscope with WiFi Camera and iPad • Camera: OM-D E-M5 Mark II • Camera: Pen E-PL8 More information: Thu, 24 May 2018 13:31:00 +0000 Quasi-epitaxial Growth of [Ru(bpy)3]2+ by Confinement in Clay Nanoplatelets Yields Polarized Emission Cryogenic ion etched biosamples were prepared by Leica Microsystems to support research on polarized emission by orientation of photoluminescent organic molecules. In this article, the authors present a nano confinement strategy to control the spatial orientation and emission polarization of phosphorescent metal complexes. Click here to read the full text article. Thu, 24 May 2018 08:15:00 +0000 The effect of magnesium on the corrosion of hot‐dip galvanized steel in chloride containing environments In this article published in Materials and Corrosion 65. No. 9, T. A. Keppert et al. report on the testing of three different hot-dip galvanizing alloys in salt spray tests. A Leica EM TIC 3X was used to polish cuts of metallographic cross-sections for EDX analysis of areas of interest. Click here to read the full text article. Thu, 24 May 2018 08:13:00 +0000 Role of Phase Morphology on the Damage Initiated Self-healing Behavior of Ionomer Blends Self-healing materials based on polymer blends made of ionomers are interesting materials from both scientific and technological point of view. The self-healing behaviors of such materials were investigated by Mohammed Arifur Rahman et al. For the research reported in this article, the authors used a Leica EM UC7 ultramicrotome with an EM FC7 cryo chamber for preparation of the specimens for TEM analysis. Click here to read the full text article Thu, 24 May 2018 08:11:00 +0000 Triple-beam Ar-Ion-Milling with a Rotary Stage to Decorate Grain Boundaries and Substructures in Rock Salt Decoration of grain boundaries in polycrystalline rocks has long been of importance in structural geology. This is because the recrystallized grain size in monomineralic rock is a good indicator of  paleostress conditions. Understanding the mechanical properties of rock salt and its deformation behavior is key to predicting the  long-term stability of nuclear waste repositories and contributes to our understanding of the dynamics of salt-related sedimentary basins which host the majority of oil and gas accumulations on earth. Thu, 24 May 2018 08:03:00 +0000 Putting the Optical Microscope Under the Microscope to Achieve Atomic Accuracy Over the last two decades, scientists have discovered that the optical microscope can be used to detect, track and image objects much smaller than their traditional limit—about half the wavelength of visible light, or a few hundred nanometers. Thu, 24 May 2018 06:29:00 +0000 Infrared Microscopy: Fast Tool for Colorectal Cancer Diagnosis The so-called IR imaging is now as fast as conventional procedures and brings with it some advantages. Wed, 23 May 2018 04:34:00 +0000