Imaging & Microscopy en Using Light-Emitting Nanoparticles to Avoid Cell Damage in Deep-Tissue Imaging A research team has demonstrated how light-emitting nanoparticles, developed at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), can be used to see deep in living tissue. The specially designed nanoparticles can be excited by ultralow-power laser light at near-infrared wavelengths considered safe for the human body. They absorb this light and then emit visible light that can be measured by standard imaging equipment. Thu, 16 Aug 2018 05:41:00 +0000 Super-Resolution Meets Quantum Optics Super-resolution is a general term for methods surpassing the diffraction limit in optical microscopy, imaging details finer than half of the visible wavelength. Each of these methods employs a different source of extra information such as non-linearity or a time dependent scene. We present here two methods, which for the first time apply the quantum nature of light as a source of extra information in order to break the diffraction limit. Introduction Wed, 15 Aug 2018 11:01:00 +0000 Prior Scientific Opens New Office in China Prior Scientific a designer and manufacturer of precision positioning devices, automated solutions and components announces the opening of its new office in Suzhou, China to give local presence with support and sales. CEO Tom Freda said: “The opening of this new office in China marks another milestone in the proud history of Prior. This new office will allow us to have a local presence in the China region, so we can support our customer base more closely” Mon, 13 Aug 2018 12:47:00 +0000 Observing Cellular Dynamics from 2D to 3D Many complex tubular organs, including kidney, lung, the intestine and several glands, form from a flat layer of cells during animal development. Failure of proper tube formation underlies severe congenital malformations such as Spina Bifida, and the failure to maintain tube architecture for instance underlies Polycystic Kidney Diseases. Sat, 11 Aug 2018 04:35:00 +0000 Flat Lenses Bring Tiny Features into Focus High-numerical-aperture optical lenses offer very high resolution and are particularly useful for low-light-intensity applications, such as single-photon optics. The numerical aperture is a measure of the conical angle of light that can be collected by the lens and, reciprocally, how tightly a beam of light can be focused. The larger the numerical aperture, the higher the resolution and the closer the lens can be to the object to be imaged. Fri, 10 Aug 2018 07:22:00 +0000 Real-Time Imaging: Revealing How Well Cancer Drugs Hit their Targets Scientists have developed a technique that allows them to measure how well cancer drugs reach their targets inside the body. It shows individual cancer cells in a tumour in real time, revealing which cells interact with the drug and which cells the drug fails to reach. In the future, the findings, published in Nature Communications, could help clinicians decide the best course and delivery of treatment for cancer patients. Tue, 07 Aug 2018 04:51:00 +0000 New Digital Microscopy Platform Apeer from Zeiss Zeiss introduces Apper, a cloud-based digital microscopy platform where users will be able to automatically process images in the cloud by leveraging application workflows for 3D reconstructions, staining or segmenting. Statement from Dr. Markus Weber, Head of the Microscopy business group Mon, 06 Aug 2018 17:42:00 +0000 Scanning Tunnelling Microscopy: High-Resolution Imaging of Nanoparticle Surface Structures Using scanning tunnelling microscopy (STM), extremely high resolution imaging of the molecule-covered surface structures of silver nanoparticles is possible, even down to the recognition of individual parts of the molecules protecting the surface. This was the finding of joint research between China and Finland, led in Finland by Academy Professor Hannu Häkkinen of the University of Jyväskylä. Mon, 06 Aug 2018 07:19:00 +0000 Protein Visualization: New Method Refines Cell Sample Analysis Innovation in the field of biomedicine: Researchers at the University of Zurich have developed a novel method which increases more than tenfold the number of proteins that can be visualized per sample, making it possible to generate a comprehensive map of cellular organization across the various cellular states. This highly sophisticated and refined view can be used to advance precision medicine and is already being applied in cancer medicine. Mon, 06 Aug 2018 05:43:00 +0000 Advanced Microscopy Technique Reveals New Aspects of Water at the Nanoscale Level A new microscopy technique developed at the University of Illinois at Chicago allows researchers to visualize liquids at the nanoscale level — about 10 times more resolution than with traditional transmission electron microscopy — for the first time. Thu, 02 Aug 2018 06:49:00 +0000 TEM Analysis of Polyethylene-EPDM Blends The development of an innovative staining method for TEM analysis was performed in order to study blends of Very Low Density Polyethylene (VLDPE) and Ethylene – Propylene - Diene Rubber (EPDM). The blends were prepared by melt mixing different PE and EPDM samples and using different EPDM concentrations. In particular the distribution of the elastomeric component in PE matrix and the morphology of the rubber were investigated. Introduction Wed, 01 Aug 2018 12:44:00 +0000 Hitachi High-Technologies launches the SU7000 Hitachi High-Technologies Corporation announced that it will launch the SU7000, a Schottky field emission scanning electron microscope (FE-SEM) that incorporates a large specimen chamber, enhanced versatility, and high throughput with simultaneous acquisition as well as analysis of various signal types. Tue, 31 Jul 2018 19:09:00 +0000 Park Systems AFM Scholarship Awards Park Systems, a manufacturer of atomic force microscopes (AFM) awarded the Park Systems AFM Scholarships to two new young scientists from Europe: 1st Prize goes to Nasim Bosh from HFU Furtwangen, Campus Tuttlingen, Germany 2nd Prize goes to Florina Serdean from Technical University of Cluj-Napoca, Romania Thu, 26 Jul 2018 09:24:00 +0000 Liquid Microscopy Technique Reveals New Problem with Lithium-Oxygen Batteries Using an advanced, new microscopy technique that can visualize chemical reactions occurring in liquid environments, researchers have discovered a new reason lithium-oxygen batteries — which promise up to five times more energy than the lithium-ion batteries that power electric vehicles and cell phones — tend to slow down and die after just a few charge/discharge cycles. They report their findings in the journal Nano Energy. Wed, 25 Jul 2018 10:25:00 +0000 WILEY Introduces EKB on Electron Probe Microanalysis Electron probe microanalysis (EPMA) is an analytical technique widely used for determining the elemental composition of solid specimens. It can produce maps showing the distribution of elements over the surface of a specimen while also accurately measuring their concentrations. Tue, 24 Jul 2018 14:20:00 +0000 New Giant Virus in Free-Living Amoeba Two similar Mimivirus-like giant viruses KLS-5 and KSL-5x were isolated from a sycamore tree. One isolate, KSL-5, was associated with a small satellite virus. The phylogenetic analysis of the host amoeba identified it as Saccamoeba lacustris. Only S. lacustris strains were susceptible to the new giant virus KLS-5 indicating a highly species-specific virus system in Saccamoeba lacustris. The name Platanovirus saccamoebae for the new giant virus is proposed. Introduction Fri, 20 Jul 2018 09:20:00 +0000 The Most Sensitive on Record Unrivalled SENSITIVITY, unparalleled field of view... the wait is nearly over... VISIT ANDOR HERE AND SIGN UP NOW TO GET THE FIRST LOOK! Thu, 19 Jul 2018 12:55:00 +0000 Complete Fly Brain Imaged at Nanoscale Resolution Two high-speed electron microscopes. 7,062 brain slices. 21 million images. For a team of scientists at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia, these numbers add up to a technical first: a high-resolution digital snapshot of the adult fruit fly brain. Thu, 19 Jul 2018 12:06:00 +0000 Splitting Water: Nanoscale Imaging Yields Key Insights In the quest to realize artificial photosynthesis to convert sunlight, water, and carbon dioxide into fuel – just as plants do – researchers need to not only identify materials to efficiently perform photoelectrochemical water splitting, but also to understand why a certain material may or may not work. Now scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) have pioneered a technique that uses nanoscale imaging to understand how local, nanoscale properties can affect a material’s macroscopic performance. Thu, 19 Jul 2018 11:06:00 +0000 20th Anniversary of Imaging & Microscopy Why are you reading Imaging & Microscopy? - Send us your answer to by 1st September 2018 (Subject line: 20th Anniversary). We look forward to hearing your opinion. All submissions will be entered in a prize draw and the lucky winner will receive a little surprise. Thu, 19 Jul 2018 07:00:00 +0000 Dynamic Live-Cell Processes in 3D Super Resolution with SpinSR by Olympus The Olympus IXplore SpinSR combines super resolution, confocal and widefield imaging in one easy-to-use system with fast switching between imaging modes. With the ability to resolve features down to 120 nm, IXplore SpinSR enables fast imaging of live cells with less phototoxicity and photobleaching. Olympus silicone immersion objectives improve brightness and reduce spherical aberration for accurate Z-axis information and better 3D reconstruction. Wed, 18 Jul 2018 15:46:00 +0000 Nano Innovation Award 2018 for Important Future Applications in Nanosciences On July 13, the Nano Innovation Award 2018 was awarded at the Center for NanoScience (CeNS) of the Ludwig-Maximilians-Universität (LMU) Munich. Two young researchers received the award for promising results as part of their master's or doctoral thesis in application-oriented nanosciences. The Bavarian-wide prize is endowed with €9,000 and is awarded annually by a jury of experts from science and business. Tue, 17 Jul 2018 07:47:00 +0000 MultiHarp 150 – New Generation of Timing Electronics PicoQuant is proud to announce the MultiHarp 150, its newest generation of bench-top event timers with USB 3.0 interface. Tue, 17 Jul 2018 06:13:00 +0000 JPK Instruments Joins Bruker Corporation Bruker Corporation has recently acquired JPK Instruments AG (JPK). In 2017, JPK Instruments had revenue of approximately 10 million Euro. JPK provides microscopy instrumentation for biomolecular and cellular imaging, as well as force measurements on single molecules, cells and tissues. JPK adds in-depth expertise in live-cell imaging, cellular mechanics, adhesion, and molecular force measurements, optical trapping, and biological stimulus-response characterization to Bruker. Financial details of the transaction were not disclosed. Mon, 16 Jul 2018 06:13:00 +0000 New Microscopy Works at Extreme Heat A new microscopy technique allows researchers to track microstructural changes in real time, even when a material is exposed to extreme heat and stress. Recently, researchers show that a stainless steel alloy called alloy 709 has potential for elevated temperature applications such as nuclear reactor structures. Tue, 10 Jul 2018 12:30:00 +0000