Science Overview | Imaging & Microscopy - Research, Development, Production

Sep. 19, 2019
ScienceLight Microscopy
Plasmonic Nanofocusing Spectroscopy
It is notoriously difficult to funnel light into subwavelength, nanometer-sized dimensions. The diffraction limit apparently restricts the resolution of all-optical spectroscopy to a few hundreds of nanometers at visible wavelengths. Here, ...
Sep. 19, 2019
ScienceImage Processing
Machine Learning in the Microscopy Lab
Digitalization is increasingly penetrating materials microscopy. Microscopic image acquisition is increasingly automated, enabling large sample areas or even complex materials to be digitally imaged. The data-driven methods of machine ...
Aug. 19, 2019
ScienceLight Microscopy
Volumetric Fluorescence Imaging
Fluorescence microcopy is one of the most widely used tools for investigating the dynamics of biological systems. Such dynamics, for example the propagation of neural signals in the brain, often plays out in all three spatial dimensions. ...
Jul. 12, 2019
ScienceElectron and Ion Microscopy
Secondary Electron Energy Matters
Secondary Electron (SE) Imaging in Scanning Electron Microscopes is fundamental to Materials Science including polymers - yet it lacks nanoscale chemical information, unless samples are stained. Change comes when sets of images using SEs ...
Jul. 01, 2019
ScienceScanning Probe Microscopy
Determing the Elasticitiy of Graphene
Atomic force microscopy based nanoindentation technique provides a powerful approach to determine the elasticity of graphene. From the recorded force-displacement response, free standing graphene shows stiffness of 1TPa, which is the ...
Jun. 20, 2019
ScienceScanning Probe Microscopy
Stretching DNA Using Cryo-Force Spectroscopy
Mechanical properties of micrometer long DNA have mainly been probed at room temperature with a force resolution limited by thermal fluctuations. Cryo-force spectroscopy combined with computer simulations now enables to quantify adhesion ...
Jun. 19, 2019
ScienceImage Processing
The BigDataViewer Ecosystem
One of the defining characteristics of many types of modern microscopy is that we have well and truly entered the era of Big Data, thanks to ever-increasing spatial and temporal resolution. Once the size of a dataset gets beyond the local ...
Jun. 18, 2019
ScienceElectron and Ion Microscopy
ITO Substrates for CLEM of Fibril Proteins
Correlative light and electron microscopy in a SEM is usually performed using glass commercial substrates coated with indium-thin oxide. These substrates however show a patchy background unavoidably imaged when fibril proteins are ...

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